Dr. Vainav Patel



 

 

 


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Scientist 'D' & Head

Division of Biochemistry
Phone : +(91-22) 2419-2020 ,
Email  : patelv@nirrh.res.in, vainavp@gmail.com

Academic Background

  • M.Sc. D.A.V.V. Indore (Biochemistry; 1996)
  • Ph.D. University of Mumbai (Applied Biology; 2003)

Professional Experience

Scientist D NIRRH
2013-Till Date
Ramalingaswami Fellow NIRRH
2011-Till Date
Research Fellow (Full Time Employee) National Institutes of Health, USA
2008-2011
Post Doctoral Fellow National Institutes of Health, USA.
2003- 2008

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Research Interests

  • Viral pathogenesis and genomics

  • Immunology

  • Vaccine design

Publications (Last 10)

  1. Ajbani SP, Velhal SM, Kadam RB, Patel VV, Bandivdekar AH. Immunogenicity of Semliki Forest virus based self-amplifying RNA expressing Indian HIV-1C genes in mice. Int J Biol Macromol. 2015 Sep 8;81:794-802. JIF: 3.1

  2. Valentin A1, Li J, Rosati M, Kulkarni V, Patel V, et al.: Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques. Hum Vaccin Immunother. 2015;11(8):2005-11. doi: 10.1080/21645515.2015.1016671. JIF: 2.3(On line publication 2007)

  3. Rashmi Jalah, Viraj Kulkarni, Vainav Patel et al. DNA and Protein Co-Immunization Improves the Magnitude and Longevity of Humoral Immune Responses in Macaques. PLoS ONE 2014, 9(3): e91550. JIF: 3.73

  4. Vainav Patel, Rashmi Jalah, Viraj Kulkarni et al. DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous SIV challenge. PNAS, 2013, 110:297580. JIF: 9.681

  5. Rashmi Jalah, Vainav Patel, Viraj Kulkarni et al. IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques. Hum Vaccin Immunother. Nov 1, 2014, 8(11), Pages 1620 1629 JIF: 3.577

  6. Kulkarni V, Jalah R, Ganneru B, Bergamaschi C, Alicea C, von Gegerfelt A, Patel V et al. Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques. Vaccine 2011 Sep 9; 29(39): 6742-54. JIF: 3.700

  7. Patel, V., Valentin, A., Kulkarni, V. et al. Long-lasting humoral and cellular responses and mucosal dissemination after intramuscular DNA immunization. Vaccine, 2010, 28(30): 4827-4836. JIF: 3.700

  8. Valentin, A., von Gegerfelt, A.S., Rosati, M., Miteloudis, G., Alicea, C., Bergamaschi, C., Jalah, R., Patel, V.et al. Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit. Vaccine, 2010, 28(8): 1962-1974. JIF: 3.700

  9. Margherita Rosati, Cristina Bergamaschi, Antonio Valentin, Viraj Kulkarni, Rashmi Jalah, Candido Alicea, Vainav Patel et al. DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge. PNAS, Sept 15, 2009, 106(37): 15831-15836. JIF: 9.681

  10. Valentin, A., Chikhlikar, P., Patel, V. et al. Comparison of DNA vaccines producing HIV-1 Gag and LAMP/gag chimera in rhesus macaques reveals antigen-specific T cell responses with distinct phenotypes. Vaccine, 2009, 27(35): 4840-4849. JIF: 3.700

Ongoing Research Projects

  • Deep sequencing based variation analysis of broadly neutralizing antibody epitopes from HIV-1 clade C infected individuals from India

  • Study of evolution of viral signatures and host immunity in HIV pathogenesis

  • To study the role of CD4+ regulatory T cells (Treg) in HIV- infected immunologically discordant individuals undergoing anti-retroviral therapy (ART)

  • Design and development of an indigenous plasma Viral Load estimation assay for HIV-2

  • Microfluidics-based approach to on-demand fractionation of blood components