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Scientist 'D'

Innate Immunity
Phone : +( 91-22) 2419 2017
Email  : guptat@nirrh.res.in

Academic Background

Professional Experience

Research Interests

Awards & Achievements

• Young Women Bioscientist, 2004, by Indian Science Congress, Chandigarh

• CSIR Young Scientist, Life Sciences, 2003 for work on identification of role of lung surfactant proteins A and D in host defense against aspergillosis.

• Charles Richets Prize, 2000 for the outstanding contributions on "Aspergillosis" in the area of Allergy, Asthma and Clinical Immunology, conferred by Indian College of Allergy, Asthma and Applied Immunology.

• INSA Young Scientist Medal (Medical Sciences, 1998) for "Immunopathogenesis of Aspergillosis".

• Indian Pharmaceutical Association Silver Medal for Ist position in M.Pharm. in 1992.

• G.P.Nair Award and K.K.Acharjee Fellowship by Indian Drug Manufacturers Association Bombay and University of Delhi for Ist position in B.Pharm. in Delhi University in 1990.

Publications (Last 10)

1. Madan T, Reid KB, Clark H, Singh M, Nayak A, Sarma PU, Hawgood S, Kishore U. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis. Mol Immunol. 47:1923-30, 2010

2. Chaudhary N, Mahajan L, Madan T, Kumar A, Raghava GP, Katti SB, Haq W, Sarma PU. Prophylactic and Therapeutic Potential of Asp f1 Epitopes in Naïve and Sensitized BALB/c Mice. Immune Network 9(5):179-91, 2009

3. Waters P, Vaid M, Kishore U, Madan T. Lung surfactant proteins A and D as pattern recognition proteins. Adv Exp Med Biol. 2009;653:74-97. Review.

4. Upadhyay SK, Mahajan L, Ramjee S, Singh Y, Basir SF, Madan T. Identification and characterization of a laminin-binding protein of Aspergillus fumigatus: extracellular thaumatin domain protein (AfCalAp). J Med Microbiol. Jun;58(Pt 6):714-22, 2009

5. Singh M, Madan T, Waters P, Sonar S, Singh SK, Kamran MF, Bernal AL, Sarma PU, Singh VK, Crouch EC, Kishore U. Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis. Mol Immunol.  Jul;46(11-12):2363-9, 2009

6. Upadhyay SK, Mahajan L, Ramjee S, Singh Y, Basir SF, Madan T. Identification and characterization of a laminin-binding protein of Aspergillus fumigatus:extracellular thaumatin domain protein (AfCalAp). J Med Microbiol. 58:714-22, 2009

7. Singh M, Madan T, Waters P, Sonar S, Singh SK, Kamran MF, Bernal AL, Sarma PU, Singh VK, Crouch EC, Kishore U. Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis. Mol Immunol. 46:2363-9, 2009.

8. Gautam P, Shankar J, Madan T, Sirdeshmukh R, Sundaram CS, Gade WN, Basir SF, Sarma PU. Proteomic and transcriptomic analysis of Aspergillus fumigatus on exposure to amphotericin B. Antimicrob Agents Chemother. 52:4220-7, 2008.

9. Mahajan L, Madan T, Kamal N, Singh VK, Sim RB, Telang SD, Ramchand CN, Waters P, Kishore U, Sarma PU. Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages. Int Immunol. 20:993-1007, 2008.

10. Indian Genome Variation Consortium. Genetic landscape of the people of India: a canvas for disease gene exploration. J Genet. 87:3-20, 2008.

Present students

• Mr. Ajit Kumar Yadav

Past student

Projects

• Proteomics of medically important fungus Aspergillus fumigatus to identify potential allergens/ antigens, virulent factors and proteins and pathways involved in drug resistance (Funded by Department of Science and Technology)

• Task Force on Infectious disease Handling, Storage and Research Facilities [COR0011] (Funded by Council of Scientific and Industrial Research)

• Task Force on Identification of potential drug targets [SMM003] (Funded by Council of Scientific and Industrial Research (CSIR)

• Task Force on “Asthmatic & Allergic Disorders Mitigation mission” TFBG (Funded by Council of Scientific and Industrial Research)

• Molecular Mechnaisms of host-pathogen interactions : Role of lung surfactant proteins in genetic predisposition to respiratory infectious diseases GAP0008 (Funded by Indian National Science Academy Young Scientist Project)