Dr. Taruna Madan Gupta



 

 

 

 

 

 

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Scientist 'D'

Innate Immunity
Phone : +( 91-22) 24192049
Email  : guptat@nirrh.res.in

Academic Background

  • B.Pharm University of Delhi College of Pharmacy, 1989
  • M.Pharm University of Delhi College of Pharmacy, 1991
  • Ph.D University of Delhi College of Pharmacy, and Institute of Genomics and Integrative Biology, 1999

Professional Experience

Scientist E-I Institute of Genomics and Integrative Biology, Delhi
2005-2007
Scientist C Institute of Genomics and Integrative Biology, Delhi
2002-2005
Visiting scientist MRC Immunochemistry Unit, Oxford
June- September, 2000
Senior Research Associate Institute of Genomics and Integrative Biology, Delhi
1999-2002
Research Associate Institute of Genomics and Integrative Biology, Delhi
1997-1999

 

 

 

 

 

Research Interests

  • Innate immunity in host defense against infections and malignancy for prevention, diagnosis and therapy of human disease
  • Evaluation of innate immune molecules as microbicides for prevention of STIs including HIV
  • Role of collectins, innate immune molecules, in uterine biology, pregnancy maintenance and immunoprivilege of testis
  • Aspergillosis : diagnosis, pathogenesis and therapy

Awards & Achievements

  • Young Women Bioscientist, 2004, by Indian Science Congress, Chandigarh

  • CSIR Young Scientist, Life Sciences, 2003 for work on identification of role of lung surfactant proteins A and D in host defense against aspergillosis.

  • Charles Richets Prize, 2000 for the outstanding contributions on "Aspergillosis" in the area of Allergy, Asthma and Clinical Immunology, conferred by Indian College of Allergy, Asthma and Applied Immunology.

  • INSA Young Scientist Medal (Medical Sciences, 1998) for "Immunopathogenesis of Aspergillosis".

  • Indian Pharmaceutical Association Silver Medal for Ist position in M.Pharm. in 1992.

  • G.P.Nair Award and K.K.Acharjee Fellowship by Indian Drug Manufacturers Association Bombay and University of Delhi for Ist position in B.Pharm. in Delhi University in 1990.

Publications (Last 10)

  1. Gautam P, Upadhyay SK, Hassan W, Madan T, Sirdeshmukh R, Sundaram CS, Gade WN, Basir SF, Singh Y, Sarma PU. Transcriptomic and Proteomic Profile of Aspergillus fumigatus on Exposure to Artemisinin. Mycopathologia. 2011 Jul 14.

  2. Yadav AK , Madan T, Bernal AL. Surfactant proteins A and D in pregnancy and parturition. Front Biosci (Elite Ed). 2011 Jan 1;3:291-300. Review.

  3. Madan T, Reid KB, Clark H, Singh M, Nayak A, Sarma PU, Hawgood S, Kishore U. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis.  Mol Immunol. 47:1923-30, 2010

  4. Chaudhary N, Mahajan L, Madan T, Kumar A, Raghava GP, Katti SB, Haq W, Sarma PU. Prophylactic and Therapeutic Potential of Asp f1 Epitopes in Naïve and Sensitized BALB/c Mice.  Immune Network 9(5):179-91, 2009

  5. Waters P, Vaid M, Kishore U, Madan T. Lung surfactant proteins A and D as pattern recognition proteins.  Adv Exp Med Biol. 2009;653:74-97. Review.

  6. Upadhyay SK, Mahajan L, Ramjee S, Singh Y, Basir SF, Madan T. Identification and characterization of a laminin-binding protein of Aspergillus fumigatus: extracellular thaumatin domain protein (AfCalAp).  J Med Microbiol. Jun;58(Pt 6):714-22, 2009

  7. Singh M, Madan T, Waters P, Sonar S, Singh SK, Kamran MF, Bernal AL, Sarma PU, Singh VK, Crouch EC, Kishore U. Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis.  Mol Immunol.  Jul;46(11-12):2363-9, 2009

  8. Upadhyay SK, Mahajan L, Ramjee S, Singh Y, Basir SF, Madan T. Identification and characterization of a laminin-binding protein of Aspergillus fumigatus:extracellular thaumatin domain protein (AfCalAp).  J Med Microbiol . 58:714-22, 2009

  9. Singh M, Madan T, Waters P, Sonar S, Singh SK, Kamran MF, Bernal AL, Sarma PU, Singh VK, Crouch EC, Kishore U. Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis.  Mol Immunol . 46:2363-9, 2009.

  10. Gautam P, Shankar J, Madan T, Sirdeshmukh R, Sundaram CS, Gade WN, Basir SF, Sarma PU. Proteomic and transcriptomic analysis of Aspergillus fumigatus on exposure to amphotericin B.  Antimicrob Agents Chemother.  52:4220-7, 2008.

Post-doctoral fellow

  • Dr. Aghila Rani KG, ICMR PDF

Present students

  • Mr. Ajit Kumar Yadav, ICMR SRF
  • Mr. Hrishikesh Pandit, NIRRH JRF
  • Ms Sharon Kay, CSIR JRF
  • Ms Sushama Rokade, CSIR JRF

Past student

  • Ms Savneet Kaur
  • Mr.Jata Shankar
  • Ms NeelKamal
  • Ms Poonam Gautam
  • Mr.Mudit Vaid
  • Ms Lakshna Mahajan
  • Mr. Santosh Upadhyay

Projects

  • Studies to understand the tertiary structure-dependence on antimicrobial activity of 2 novel peptides (Co-I, Funded by Department of Science and Technology)

  • Proteomics of medically important fungus  Aspergillus fumigatus  to identify potential allergens/ antigens, virulent factors and proteins and pathways involved in drug resistance (Funded by Department of Science and Technology)

  • Task Force on Infectious disease Handling, Storage and Research Facilities [COR0011] (Funded by Council of Scientific and Industrial Research)

  • Task Force on Identification of potential drug targets [SMM003] (Funded by Council of Scientific and Industrial Research (CSIR)

  • Task Force on “Asthmatic & Allergic Disorders Mitigation mission” TFBG (Funded by Council of Scientific and Industrial Research)

  • Molecular Mechanisms of host-pathogen interactions : Role of lung surfactant proteins in genetic predisposition to respiratory infectious diseases GAP0008 (Funded by Indian National Science Academy Young Scientist Project)