Dr. K V R Reddy



 

 

 

 

 

 

 

Scientist 'E'

Division of Molecular Immunology
Phone : +(91-22) 2419-2016
Email  : reddyk@nirrh.res.in

Academic Background

  • M.Sc. S. V. University, Tirupati, Andhra Pradesh, India (Zoology, Reproductive Physiology; 1981)
  • Ph.D. S. V. University, Tirupati, Andhra Pradesh, India (Reproductive Physiology; 1984)

Professional Experience

Junior Research Fellow Council of Scientific and Industrial Research, S.V. University , Andhra Pradesh , India 1982-1984
Senior Research Fellow Council of Scientific and Industrial Research, S.V. University , Andhra Pradesh , India 1985-1986
Senior Research Officer Central Sericulture Research and Training Institute (Central Silk Board), Mysore , India 1986-1994
Scientist NIRRH 1994-Till Date

 

 

 

 

 

Research Interests

  • Immunology

  • Transgenic and knockout

  • Antimicrobial Peptides
     

Awards & Achievements

  • Received Swarnakanta Dingley National Award for scientific research achievements for the year 2005.

  • Awarded DBT Associateship by the Department of Biotechnology to carry out gene targeting and transgenic studies at Centre for Reproductive Biomedicine, Kansas Medical Centre, Kansas, USA for a period of six months in the year 2005.

  • Awarded CSB associateship by the Central Silk Board, Ministry of Commerce and Textiles, Govt. of India to visit Zhenjiamg, Jiyangsu , China for training in silk work raring 1994.

  • Received Institutional award for Professional Excellence in research from NIRRH for the year, 2002-2003 .

 

Publications (Last 10)

  1. Gupta SM, Aranha CC, Reddy KVR. Evaluation of developmental toxicity of microbicide Nisin in rats. Food and Chemical Toxicology 46: 598-603, 2008.
  2. Mangale SS, Modi DN and Reddy KVR. Identification of genes regulated by an interaction between αvβ3 integrin and vitronectin in murine deciduas. Reproduction, Fertility and Development 20: 311-319, 2008.
  3. Arun P. Sikarwar and Reddy KVR. siRNA-Mediated silencing of c-kit in mouse primary spermatogonial cells induces cell cycle arrest. Oligonucleotides 18: 145-160, 2008.
  4. Clara A, Sadhana G and Reddy KVR. Evaluation of cervico-vaginal toxicity in rabbits following exposure to Nisin gel. Cytokines 43: 63-70, 2008.
  5. Arun P Sikarwar, Murali K Rambabu and KVR Reddy. Differential regulation of gene expression in mouse spermatogonial cells after blocking c-kit-SCF interaction with RNAi. J RNAi Gene Silenc. 4, 302-311, 2008.
  6. Talwar GP, Dar SA, Rai MK, Reddy KVR, Mitra D, Kulkarni SV, Doncel GF, Buck CB, Schiller JT, Muralidhar S, Bala M, Agrawal SS, Bansal K and Verma JK. A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens. Int J Antimicrob Agents 32: 180-5, 2008.
  7. Sadhana M. Gupta, Clara C. Aranha and Reddy KVR. Expression of Toll-like receptors in rabbit vaginal epithelium following intra vaginal administration of microbicide Nisin gel. Mediators of Inflammation 23: 45-59, 2008.
  8. Yedery RD and Reddy KVR. Purification and characterization of antibacterial components from the granular hemocytes of Indian mud crab, Scylla serrata. Acta Biochimica Polonica 56: 71-82, 2009
  9. Ketkar Alhad Ashok and Reddy KVR. Oct-4: more than a pluripotent marker? Yakhteh Medical Journal. 11: 1-12, 2009 .
  10. Sadhana M. Gupta, Clara C. Aranha, Sareena D’Souza, Bellare R. Jayesh and Reddy KVR. Interaction of contraceptive antimicrobial peptide nisin with target cell membranes: implications for vaginal use as a microbicide. Contraception (In press, 2009).

Present students

  • Mr. Roshan D. Yedery
  • Mr Alhad A. Ketkar
  • Mr Mandar S. Patgaonkar
  • Mr Ameya V. Sathe

Past students

  • Dr Rajeev K. Shreemali
  • Dr Vijayalaxmi G. Gupta
  • Dr Sachin S. Mangle
  • Dr Sadhana M. Gupta
  • Dr Arun P. Sikarwar

Projects

  • Development and assessment of Resazurin Reduction Tests to assess the quality of sperm in men (Funded by WHO)

  • Development and preclinical evaluation of naturally occurring antimicrobial peptide, magainin for the prevention of STIs/HIV including unplanned pregnancies (Funded by ICMR)

  • Endometrial functional markers to evaluate implantation defects in human (Funded by ICMR)

  • Immunological and biochemical characterization of cell adhesion molecules from human spermatozoa: Role of the integrins and disintegrins in the regulation of fertility (Completed in 1999) (Funded by DBT)

  • Nisin: The antimicrobial peptide for the prevention of sexually transmitted infections including HIV/AIDS (Ongoing) (Funded by ICMR)

  • Identification and characterization of polypeptides having antimicrobial activities from hemocytes/hemolymph of Indian mud crab Scylla serrata (Ongoing) (Funded by CONRAD)

  • Generation of transgenic mouse model of male infertility to understand the basic mechanism of spermatogenesis in mice (Funded by Indo-US)

  • To delineate the role of rabbit vaginal fluid polypeptides for the prevention of STIs/HIV (Funded by International Partnership on Microbicides (IPM))

  • Identification and characterization of cationic polypeptides with antimicrobial properties from rabbit epididymis (Funded by DBT-IC MR)

  • In vitro evaluation of peptide based microbicides for anti-viral activity (Funded by DBT-ICMR)

  • Design of germ cell specific transgene constructs to investigate early events in spermatogenesis (Funded by DST)