Dr. Bhakti R Pathak



 

 

 

 

 

Scientist 'E'

Structural Biology
Phone : +(91-22) 2419-2014
Email  : pathakb@nirrh.res.in

Academic Background

  • M.Sc. University of Mumbai (Microbiology; 1996)

  • Ph.D. Cancer Research Institute, Tata Memorial Centre, Mumbai (Applied Biology; 2002)

 

Professional Experience

Post-Doctoral Fellow University of Texas Health Science Center San Antonio , USA
2002-2005
Lecturer Dept of Microbiology and Biotechnology Wilson College, Mumbai
2005-2006
Scientist NIRRH
Jan 2007 - Till Date

 

 

 

 

Research Interests

  • Cell biology

  • Cancer Biology

  • Protein-Protein interactions

Awards & Achievements

  • Awarded Research Fellowship from UGC (1997-2002) upon clearing the joint CSIR-UGC National Eligibility Test.

  • Receipient of R H Jaju Award for the best oral presentation on Elucidating the role of CRISP-3 in prostate cancer, by mid-level scientist at the 33rd Annual Convention of Indian Association for Cancer Research held at Kollam, Kerala during 13th to 15th Feb 2014.

Publications

  1. Breed AA, Gomes A, Roy BS, Mahale SD, Pathak BR. Mapping of the binding sites involved in PSP94-CRISP-3 interaction by molecular dissection of the complex. Biochim Biophys Acta (General Subjects). 2013; 1830:3019-29

  2. Anklesaria JH, Jagtap DD, Pathak BR, Kadam KM, Joseph S, Mahale SD. Prostate Secretory Protein of 94 amino acids (PSP94) binds to prostatic acid phosphatase (PAP) in human seminal plasma. PLoS One. 2013; 8(3):e58631

  3. Dupakuntla M, Pathak B, Roy BS, Mahale SD. Extracellular loop 2 in the FSH receptor is crucial for ligand mediated receptor activation. Mol Cell Endocrinol. 2012, 362:60-8

  4. Desai SS, Achrekar SK, Pathak BR, Desai SK, Mangoli VS, Mangoli RV, Mahale SD. Follicle-stimulating hormone receptor polymorphism (G-29A) is associated with altered level of receptor expression in Granulosa cells. J Clin Endocrinol Metab. 2011, 96:2805-12.

  5. Pathak BR, Breed AA, Nakhawa VH, Jagtap DD and Mahale SD. Growth inhibition mediated by PSP94 and CRISP-3 is prostate cancer cell line specific. Asian J Androl. 2010, 12:677-69

  6. Jagtap DD, Modi DN, Kumar M, Pathak BR and Mahale SD. High-affinity binding of seminal plasma PSP94 to human immunoglobulin is through the Fab domain. Biochim Biophys Acta (proteins and proteomics). 2010, 1804:1889-94

Projects

  • From DST-SERC under the Fast Track Scheme for Young Scientists for project entitled “Exploring the biological significance and regulation of alternative splicing of PSP94” (Nov 2008- 2011)

  • From BRNS-DAE for project entitled “Analyzing the effect and mechanism of CRISP-3 upregulation during prostate tumorigenesis” (Nov 2011- 2014)