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Scientist 'E'

Division of Structural Biology
Phone : +( 91-22) 2419 2015
Email  : mahales@nirrh.res.in

Academic Background

Professional Experience

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Research Interests

Awards & Achievements

• Department of Biotechnology Overseas Associateship (long-term) for carrying out research at Wadsworth Center, New York State Department of Health, Albany, New York, USA : 1996-1997

• ICMR Swaran Kanta Dingley Award 2005

• Department of Biotechnology Overseas Associateship (short-term) for carrying out research at Wadsworth Center, New York State Department of Health, Albany, New York, USA : 2007

Publications (Last 10)

1. S. S. Chitnis, C. Selvakumar, D. D. Jagtap, R. P. Barnwal, K. V. R. Chary, S. D. Mahale and T. D. Nandedkar. Interaction of GRBI-8, a Novel Follicle Stimulating Hormone Binding Inhibitor with FSH and its Receptor. Chem Biol andDrug Design73, 637-643, 2009.

2. S. K. Achrekar, D. N. Modi, S. K. Desai, V. S. Mangoli, R. V. Mangoli, S. D. Mahale. Poor ovarian response to gonadotropin stimulation is associated with SNP in the 5’ untranslated region of FSH receptor. RBM Online 18, 509-515, 2009.

3. M. Kumar, D. D. Jagtap, S. D.Mahale, V. Prashar, A. Kumar, A. Das, S. C. Bihani, J. L Ferrer, M. V. Hosur, M. Ramanadham. Crystallization and preliminary X-ray differaction analysis of human seminal plasma protein PSP94. Acta Crystallogr. 65, 389-391, 2009.

4. M. Dupakuntla, J. D. Ghosalkar and S. D. Mahale. Characterization of peptide 20-30 of follicle stimulating hormone receptor as an antagonist of receptor activity: Significance of charged residues. Chemical Biology and Drug Design 73, 108-114, 2009.

5. S. K. Achrekar, D. N. Modi, S. K. Desai, V. S. Mangoli, R. V. Mangoli, S. D. Mahale. Follicle-stimulating hormone receptor polymorphism (Thr 307Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women. Fertility & Sterility 91, 432-439, 2009.

6. S. S. Chitnis, R. M. Navlakhe, G. C. Shinde, S. J. Barve, S. D’Souza, S. D. Mahale and T. D. Nandedkar. Granulosa cell apoptosis induced by a novel FSH binding inhibitory peptide from human ovarian follicular fluid. J. Histochem. Cytochem. 56, 961-968, 2008.

7. J. D. Ghosalkar, S. J. Dharma, T. D. Nandedkar and S. D. Mahale. Identification of the region 285-309 of follicle stimulating hormone receptor as a bioneutralizing epitope. J. Reprod. Immunol. 74, 24-33, 2007.

8. D. D. Jagtap, A. Narahari, M. J. Swamy and S. D. Mahale. Disulphide bond reduction and S-carboxamidomethylation of PSP94 affects its conformation but not the ability to bind immunoglobulin. Biochim. Biophys. Acta. 1774, 723-731, 2007.

9. P. R. Wadia , S. D. Mahale, T. D. Nandedkar. Effect of the human follicle-stimulating hormone-binding inhibitor and its N-terminal fragment on follicle-stimulating hormone-induced progesterone secretion by granulosa cells in vitro. J. Biosci. 32, 1185-1194, 2007.

10. Das, V. Prashar, S. D. Mahale, L. Serre, J. L. Ferrer and M. V. Hosur. Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates. PNAS 103, 18464-18469, 2006.

Present students

Past student

Projects

• Human beta microseminoprotein: Studies on structural characterization and understanding its role in modulation of follicle stimulating hormone and sperm function ( Funded by Department of Biotechnology)

• ICMR Biomedical Informatics Centre ( Funded by Indian Council of Medical Research)

• Implications of follicle stimulating hormone signaling in prostate pathophysiology ( Funded by ICMR Medical Innovation Fund)

• Expression of follicle stimulating hormone receptor in granulosa cell and its association with altered ovarian response to gonadotropin treatment ( Funded by Board of Research in Nuclear Sciences, Department of Atomic Energy)