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Scientist 'F'

Gamete Immunobiology
Phone : +(91-22) 2419-2005
Email  : kholev@nirrh.res.in , kholevv@icmr.org.in

Academic Background

• M.Sc. University of Pune (Zoology, 1973)
• Ph.D. University of Pune (Zoology;1978)

Professional Experience

Research Interests

• Epididymal Maturation

• Ovarian autoimmunity

• Endometriosis

Awards & Achievements

• Predoctoral Scholarship, University of Poona , 1973

• Junior Research Fellowship ,University Grants Commission, 1973-1977

• USSR Govt Post Doctoral Fellowship, 1979 -1983

• WHO Research Training Grant (April 1995-March 1996) to work in the laboratory of Prof. John Herr, Dept. of Cell Biology, University of Virginia, Charlottesville, USA.

• Fogarty Post doctoral fellowship (January 2000 – January 2001) to work at the Recombinant Gamete Contraceptive Vaccinogens Center , Dept. of Cell Biology, University of Virginia , USA .

• Mellon Twinning Grant from CONRAD for 4 years (2002-2006) In collaboration with Prof John C Herr, University of Virginia

Publications (Last 10)

1. Joshi SA, Ranpura SA, Khan SA, Khole V V. Monoclonal antibodies to epididymis specific proteins using mice rendered immune tolerant to testicular proteins. J Andrology , 24(4): 30-39, 2003.

2. Khole V V. Epididymis as a target for contraception. Ind. J. Exptl. Biol., 41: 764-772, 2003.

3. Wakle M, Joshi S and Khole V. Testis specific autoantigen 70 (TSA70) plays a role in motility. J Andrology , 26(6) 761-771, 2005.

4. Pires ES, Parte PP, Meherji PK, Khan SA and Khole V V. Naturally occurring anti albumin antibodies are responsible for false positivity in diagnosisof autoimmune premature ovarian failure. J Histochem Cytochem 54(4):397-405,2006.

5. Pires ES, Meherji PK , Vaidya RR, Parikh FR, Ghosalkar MN , Khole V V. Specific and sensitive immunoassays detect multiple anti-ovarian antibodies in women with infertility. J Histochem Cytochem 55: 1181-90, 2007.

6. Wakle M. and Khole V. A sperm cytoskeletal protein TSA70 is a novel phosphorylated member of Cenexin/odf2 family . Biochem Biophys Res Comm 354:528-34, 2007.

7. Gajbhiye R, Suryawanshi A, Khan S, Meherji P, Warty N, Raut V, Chehna N, Khole V. Multiple endometrial antigens are targeted in autoimmune endometriosis. Reprod Biomed Online 16:817-24, 2008.

8. Pires ES, Khole VV. A block in the road to fertility: autoantibodies to heat-shock protein 90-beta in human ovarian autoimmunity. Fertil Steril 2009 92(4): 1395-409.

9. Khan SA, Suryawanshi AR, Ranpura SA, Jadhav SV, Khole V V. Identification of Novel Immunodominant Epididymal Sperm Proteins using Combinatorial Approach. Reproduction 2009 138(1) : 81-93.

10. Nina Chehna-Patel, Geetanjali Sachdeva, Rahul Gajbhiye, Neeta Warty and Vrinda Khole.‘Spot’-ting differences between the eutopic and the ectopic endometrium of endometriosis patients. Fert Ster 2010. [Epub ahead of print]

Present students

• Ms Shagufta Khan
• Dr Amol Suryawanshi
• Dr Rahul Gjbhiye
• Ms Nina Chehna
• Ms Purvi Mande
• Mr Chetan Joshi
• Ms Asmita Chaudhari

Past students

• Dr Saurabh Joshi
• Dr Sapna Negi
• Dr Sandeep Ranpura
• Dr Monali Wakle
• Dr. Eusebio Pires

Projects

• Proteomic Approach for mapping and characterizing domain specific epididymal proteins involved in post testicular maturation (Funded by DST, New Delhi , India )

• Identification and characterization of immunodominant ovarian antigens involved in woman with IVF failures and idiopathic infertile POF patients(Funded by Indo US Programme)