Dr. Vikas Dighe



 

 

 

 

 

 

 

Scientist 'D'

National Center for Preclinical Reproductive and Genetic Toxicology
Phone: +91-22- 2419-2139
Email: dighev@nirrh.res.in

Academic Background

  • Ph.D. , Indian Veterinary Research Institute, Izzatnagar, Bareilly (Animal Biotechnology, 2014)
  • M.V.Sc., Indian Veterinary Research Institute, Izzatnagar, Bareilly (Animal Biotechnology, 1999)
  • B.V.Sc & A.H, Nagpur Veterinary College, Nagpur (Dr. Punjabrao Deshmukh Krishi Vidyapeeth, Akola)

Professional Experience

Research Fellow

National Biotechnology Center, Izatnagar-243 122, Uttar Pradesh

Sept 1999 - Aug 2000

Research Associate

National Professor Laboratory

Department of Veterinary Microbiology, CCS Haryana Agricultural University, Hisar, Haryana

Sept 2000 – Sept 2001

Research Associate

NATP Project, Department of Veterinary Microbiology, CCS Haryana Agricultural University, Hisar-125004, Haryana

Oct 2001-March 2002

Research Associate

ICMR Project , Microbial Containment Complex, National Institute of Virology, ICMR, Pune-411021, Maharashtra

March 2002 - Jan 2003

Veterinary Officer

Poultry Diagnostics Research Center of ‘Venkateshwara Hatcheries Group’ Pune, Maharashtra

Feb 2003 - March 2003

Research Associate-II

Lupin Research Park’ of Lupin LTD, Village Nande, Pune, Maharashtra

March 2003 - Aug 2003

Scientist ‘B’

NIRRH

August 2003 - August 2008

Scientist ‘C’ NIRRH August 2008- till date


Research Interests

  • Reproductive Biology
  • Toxicology
  • Bioinformatics
  • Non- human Primate Experimental Medicine.

Awards & Achievements

  • Overseas Training fellowship at Oregon National Primate Research Center (OHSU) Beaverton, Oregon USA, in the area of “Assisted Reproductive Technologies (ARTs) in non-human primates, Stem cell derivation and characterization, Epigenetic reprogramming of ES cells and Derivation of Specific pathogen free Monkey for biomedical research.
  • Qualified ICAR-National Eligibility Test
  • Awarded Indian Veterinary Research Institute-Junior Research Fellowship (1997-1999)
  • Awarded Indian Council of Agriculture Research Merit Scholarship (1992-1997)

Publications (Last 10)

  1. Vikas D. Dighe, Arvind Kumar Singh, Dimpal Thakuria and Satish Kumar (2014)
    Conformational Changes in Testis Specific Homing Peptide in Polar and Apolar Environment:  Journal of Pure and Applied Microbiology. 8(5): 4171-4176
  2. Joshi VG, Dighe VD, Thakuria D, Malik YS, Kumar S (2013) Multiple antigenic peptide (MAP): a synthetic peptide dendrimer for diagnostic, antiviral and vaccine strategies for emerging and re-emerging viral diseases. Indian J Virol. 24(3):312-20.
  3. Joshi VG, Chindera K, Singh AK, Sahoo AP, Dighe VD, Thakuria D, Tiwari AK, Kumar S. (2013) Rapid label-free visual assay for the detection and quantification of viral RNA using peptide nucleic acid (PNA) and gold nanoparticles (AuNPs) Anal Chim Acta.; 17: 795:1-7
  4. Doshi T, D'Souza C, Dighe V, Vanage G. (2012) Effect of neonatal exposure on male rats to bisphenol A on the expression of DNA methylation machinery in the postimplantation embryo. J Biochem Mol Toxicol. ; 26(9):337-43
  5. Dhumal R, Vijaykumar T,  Dighe V, Selkar N, Chawda M, Vahlia M,  Vanage.G (2012). Efficacy and Safety of a Herbo-mineral Ayurvedic formulation ‘Afrodet Plus®’ in male  rats J. Ayurveda & Integrative Medicine 2013; 4(3):158-64
  6. Doshi T, Mehta SS, Dighe V, Balasinor N, Vanage G Hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol A.Toxicology. 2011: 289(2-3):74-82
  7. Mahajan MV, Gadekar YP, Dighe VD, Kokane RD, Bannalikar AS Molecular detection of meat animal species targeting MT 12S rRNA gene. Meat Sci. 2011 88(1):23-7.
  8. Cohen NM, Dighe V, Landan G, Reynisdóttir S, Palsson A, Mitalipov S, Tanay A. DNA methylation 
    programming and reprogramming in primate embryonic stem cells. Genome Research; 19(12):2193-201, 2009.
  9. Sparman M, Dighe V, Sritanaudomchai H, Ma H, Ramsey C, Pedersen D, Clepper L, Nighot P, Wolf D, Hennebold J, Mitalipov S. Epigenetic Reprogramming by Somatic Cell Nuclear Transfer in Primates. 
    Stem Cells. 27(6):1255-1264, 2009.
  10. Dighe V, Clepper L, Pedersen D, Byrne J, Ferguson B, Gokhale S, Penedo MC, Wolf D, Mitalipov S.(2008). Heterozygous embryonic stem cell lines derived from nonhuman primate parthenotes.Stem Cells. 26(3):756-66


Projects

  1. Effect of Bisphenol A, an Endocrine Disruptor on Spermatogenesis in Common Marmoset at Cellular and Molecular level” ( as Principal Investigator Funded by SERB (DST)
  2. Effects of Oxytocin Exposure on Reproduction in Adult Male and Female Rat (as Principal Investigator Funded by Indian council of Medical Research (ICMR)
  3. Establishment of Genetically defined and Specific Pathogen free (SPF) Marmoset (Callithrix jacchus) colony. (as Principal Investigator funded by ICMR intramural grant)
  4. Study of Epigenetic changes in the rat male germ line following neonatal exposure to environmental endocrine disrupter Bisphenol-A (As Co-Investigator Funded by DST)
  5. MicroRNA Regulation in Prostate and Ovary upon Exposure to Endocrine Disruptors (as Principal Investigator funded by ICMR intramural grant)