Dr. Dhanashree Jagtap








Scientist 'C'

Structural Biology Division
Phone: 91-22-24192014
Email  : jagtapd@nirrh.res.in

Academic Background

  • Ph.D, NIRRH (Mumbai University), 2012
  • M.Sc, NIRRH (Mumbai University), 1999

Professional Experience

Scientist B

National Institute for Research in Reproductive Health (NIRRH), Mumbai

2015 till date

Scientist B

National AIDS Research Institute (NARI), Pune


Research Interests

  • Structure-function studies on proteins

  • Protein-protein interactions

  • Host restriction factors

Awards & Achievements

Best Poster award for the work entitled -Structural importance of PSP94 relevant for its function at the International Congress on Gamete Biology: Emerging Frontiers in Fertility and Contraceptive Development, National Institute of Immunology (NII), New Delhi, 22-25 Feb, 2006.

Publications (Last 10)

  • Mhatre DR, Mahale SD, Khatkhatay MI, Achrekar SK, Desai SS, Jagtap DD, Dhabalia JV, Tongaonkar HB, Dandekar SP, Varadkar AM. The rs10993994 in the proximal MSMB promoter region is a functional polymorphism in Asian Indian subjects Springerplus. 4:380-388, 2015
  • Mhatre DR, Mahale SD, Khatkhatay MI, Desai SS, Jagtap DD, Dhabalia JV, Tongaonkar HB, Desai MP, Dandekar SP, Varadkar AM. sPSP94/sPSA ratio as a diagnostic indicator to differentiate between benign prostatic hyperplasia and prostate cancer. Clin Chim Acta. 436:256-262, 2014
  • Navalakhe RM, Jagtap DD, Nayak SU, Nandedkar TD, Mahale SD. Effect of FSH receptor-binding inhibitor-8 on FSH-mediated granulosa cell signaling and proliferation. Chem Biol Drug Des, 82:178-188,2013
  • Anklesaria JH, Jagtap DD, Pathak BR, Kadam KM, Joseph S, Mahale SD. Prostate Secretory Protein of 94 amino acids (PSP94) binds to prostatic acid phosphatase (PAP) in human seminal plasma, PLoS One, 8:e58631, 2013
  • Pathak BR, Breed AA, Nakhawa VH, Jagtap DD, Mahale SD. Growth inhibition mediated by PSP94 or CRISP-3 is prostate cancer cell line specific. Asian Journal of Andrology, 12: 677-689,2010
  • Jagtap DD, Modi DN, Kumar M, Pathak BR, Mahale SD. High affinity of seminal plasma PSP94 to human immunoglobulin is through the Fab domain. Biochem Biophy Acta-Proteins and Proteomics, 1804: 1889-1894,2010
  • Kumar A, Jagtap DD, Mahale SD, Kumar M. Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer. J Mol Biol, 397, 947-956, 2010
  • Kumar M, Jagtap DD, Mahale, SD, Prashar V, Kumar A, Das A, Bihani SC, Ferrer JL, Hosur MV, Ramanadham M. Crystallization and preliminary X-ray diffraction analysis of human seminal plasma protein PSP94. Acta Crystallogr F Struct Biol Cryst Commun, 65, 389-391, 2009
  • Chitnis SS, Selvaakumar C, Jagtap DD, Barnwal RP, Chary KV, Mahale SD, Nandedkar TD. Interaction of follicle-stimulating hormone (FSH) receptor binding inhibitor-8: a novel FSH-binding inhibitor, with FSH and its receptor. Chem Biol Drug Des, 73, 637-643,2009
  • Jagtap DD, Narahari A, Swamy M J and Mahale S D. Disulphide bond reduction and S-carboxamidomethylation of PSP94 affects its conformation but not the ability to bind immunoglobulin. Biochim Biophy Acta-Proteins & Proteomics, 1774, 723-731, 2007

Projects Completed

Characterization of Tetherin/BST2 Gene Alterations in HIV Infected Long Term Non Progressors (ICMR funded)

Projects Ongoing

Evaluation of Dried Blood Spots collected on filter papers from three manufacturers stored at ambient temperature for qualitative detection of HIV-1 DNA by Abbott real time PCR method for their potential utility in the national EID programme (NACO funded)