Dr. Deepa Bhartiya



 

 

 

 

 

 

 

Scientist 'F' & Head

Stem Cell Biology
Phone : +(91-22) 2419-2012
Email  : bhartiyad@nirrh.res.in ;
deepa.bhartiya@yahoo.in

Academic Background

  • M.Sc. Punjab University , Patiala , (Zoology)
  • Ph.D. Central Drug Research Institute, Lucknow (Zoology)

 

Professional Experience

Post Doc Fellow Dept of Pathology, Uniformed Services University of Health Sciences, Bethesda , Maryland , USA
1989-1991
Fogarty Fellow Development Endocrinology Branch, National Inst. of Child and Development, National Inst of Health (NIH), Bethesda , Maryland , USA 1991-1994
Scientist Cell Biology Dept, BJ Wadia Hospital for Children, Mumbai
1995- 2000
Scientist Genetics, Reliance Life Sciences Pvt. Ltd, Mumbai 2001- 2002
Scientist NIRRH
2003- Till Date
Visiting Scientist Three months Visiting Associateship (sponsored by DBT) for Training at Buck Institute, California, USA. 2008
Visiting Scientist Trained during a three day NIH sponsored ES Cell Course at Stem Cell Centre, University of Minnesota , MO , USA 2008
Visiting Scientist

Department of Obstetrics and Gynecology Center for Women Health Research, Meharry Medical College, Nashville, Tennessee. USA

2013

 

 

 

 

 

 




Research Interests

  • Pluripotent stem cells and Regenerative medicine
  • Fertility issues of cancer patients

Awards & Achievements (since 2010)

  • Awarded ICMR International Fellowship for Senior Indian Biomedical Scientist for the year 2013-14 in the lab of Prof Al-Handy Ayman, Scientific Director, Department of Obstetrics and Gynecology, Meharry Medical College, Tennessee, USA
  • The Ranbaxy Science Scholar Award 2012 for Young Scientist in the Biomedical Sciences Stream awarded to Ms Seema Parte (PhD student), Ranbaxy Research and Development Centre, Gurgaon, Haryana on 2nd November 2012
  • Shared the prestigious Labhsetwar National Award for the year 2011 for the scientific contribution in the area of pluripotent stem cells in mammalian gonads. The award has been constituted by Drs. Lata and Anant Labhsetwar Foundation, USA and Labhsetwar Charitable trust, Nagpur. The award was conferred during the International Conference on Reproductive Health and 22nd Annual Meeting of the Indian Society for the Study of Reproduction and Fertility (ISSRF) held at New Delhi from 19th -21st February, 2012

Conferences / Training Workshops Organized (since 2010)

  • Organized a symposium cum workshop entitled “Pluripotent Stem Cells in Adult Mammalian Gonads” from 6 -7 September 2013, supported by ICMR and ISSRF.
  • Organized a Symposium on Fertility Preservation Options and Cryopreservation and PGD Workshop at NIRRH, Mumbai from 20-22 December 2011, supported by ICMR and ISSRF.
  • Helped organize Public Consultation for Western Region ICMR-DBT Guidelines for Stem Cell Research and Therapy (20th Feb, 2010) at Nehru Science Centre, Worli, Mumbai
  • Brainstorming on Human Embryonic Stem Cells, 15 – 16 January, 2010 supported by DBT
  • Hands- on Workshop on Human Embryonic Stem Cells: Differentiation and Genetic Manipulation, 18 - 23 January, 2010 supported by DBT

Publications (Last 10)

  1. Lineage specific expression of polycomb group proteins in human embryonic stem cells in vitro. Pethe P, Pursani V, Bhartiya D. Cell Biol Int. 2015 Jan 9. doi: 10.1002/cbin.10431.
  2. Stem cells, progenitors and regenerative medicine:  A Retrospection.  Deepa Bhartiya.  IJMR (accepted)
  3. Mouse ovarian very small embryonic-like stem cells resist chemotherapy and retain ability to initiate oocyte-specific differentiation. Sriraman K, Bhartiya D, Anand S, Bhutda S. Reproductive Sciences (Accepted)
  4. Isolation and characterization of stem cells in the adult mammalian ovary. Parte S, Patel H, Sriraman K, Bhartiya D. Methods Mol Biol. (2015); 1235:203-29.
  5. FSH-FSHR3 - Stem cells in ovary surface epithelium: basis for adult ovarian biology, failure, aging and cancer.  Bhartiya D, Singh J. Reproduction. (2015); 149(1):R35-R48.
  6. An ideal oocyte activation protocol and embryo culture conditions for somatic cell nuclear transfer using sheep oocytes.  Patel H, Chougule S, Chohan P, Shah N, Bhartiya D. Indian J Exp Biol. (2014); 52(10):925-34.
  7. Very small embryonic-like stem cells are involved in regeneration of mouse pancreas post-pancreatectomy. Bhartiya D, Mundekar A, Mahale V, Patel H. Stem Cell Res Therapy (2014); 5(5):106.
  8. Making gametes from pluripotent stem cells – a promising role for very small embryonic-like stem cells. Bhartiya D, Hinduja I, Patel H, Bhilawadikar R. Reproductive Biology Endocrinology (2014);   12:114.
  9. Very small embryonic-like stem cells survive and restore spermatogenesis after busulphan treatment in mouse testis. Anand S, Bhartiya D, Sriraman K, Patel H, Manjramkar DD. J Stem Cell Res Ther (2014); 4:216.
  10. Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. Pethe P, Nagvenkar P, Bhartiya D. BMC Cell Biol. (2014); 15(1):18.

Book Chapters

  • Bhartiya D. Altered stem cell function due to changing environment impacts reproductive health. ISSRF Newsletter February 2014.
  • Bhartiya D, Nagvenkar P, Sriraman K, Shaikh A. An overview of pluripotent stem cells. In: “Pluripotent Stem Cells”, 2013. Eds: Bhartiya D, Lenka N. Publisher – InTech
  • Nagvenkar P and Bhartiya D. Clinical trials with stem cells: National and International Scenario.  In:  “Regulatory   Requirement in Drug development and Clinical Research”, 2013. Eds:  Kshirsagar N, Kulkarni T, Desai A, Shah J. Publisher-ICMR
  • Shaikh A and Bhartiya D. Pluripotent stem cells in bone marrow and cord blood. In: “Blood Cells- An Overview of Studies in Hematology”, 2012. Ed: Moschandreou TE. Publisher – InTech
  • Pethe P, Bhartiya D. Propagation of human embryonic stem cells: Role of TGF b. In:  “Stem Cells and Cancer Stem Cells”, Volume 6. , 2012, Ed: Hayat MA. Publisher – Springer
  • Bhartiya D. Oncofertility: An Emerging area of translational research in the field of reproductive biotechnology. ISSRF Newsletter February 2012.

Editor of Special Issues in Pubmed Cited International Journals

  • Invited to co- edit a special issue on Stem Cells in Reproductive Tissues: from Basics to the Clinics in Journal of Biomedicine and Biotechnology, Hindawi Publications along with Dr Irma Virant-Klun, Ljubljana; Prof Xuan Jin, China and Dr Thomas Skutella, Germany.
  • Invited to guest co-edit a special issue for Stem Cells International (Hindawi Publishers) entitled "Multipotent to Pluripotent Properties of Adult Stem Cells" along with Dr KR Boheler and Dr P Rameshwar
  • Invited as Editor along with Dr Nibedita Lenka from NCCS for a book entitled "Pluripotent Stem Cells", ISBN: 980-953-307-708-1, Intech Publishers

International Conferences Attended

  1. Novel Stem Cells and Vesicles Symposium, Providence, Rhode Island, USA from October 29-31, 2014.
  2. International Federation of Fertility Societies and American Society for Reproductive Medicine held in Boston, USA from October 12-17, 2013
  3. Second Baltic Stem Cell Meeting, held at Szczecin, Poland from 31st May-2nd June, 2013.   Invited as Faculty, Chairperson and Speaker
  4. Cell Science and Stem Cell Research 2011, held at Philadelphia, USA from 29th November – 1st December, 2011, Organized by OMICS group. Invited for oral presentation
  5. 2nd World Congress on Fertility Preservation, held in Florida, USA from 8- 10 December, 2011
  6. 7th Biennial Meeting being held at Cold Spring Harbor Laboratory, Long Island, New York on germ cells from 5th – 9th October, 2010.
  7. Oncofertility Consortium Meeting organized by Teresa Woodruff at NW University, Chicago, USA from 11 Sept– 18 Sept 2009

Present students

Ms Sandhya Anand
Mr Hiren Patel
Ms Ambreen Shaikh
Ms Varsha Pursani
Ms Aditi Waje

Past student

Ms Prajakta Berde (M.Sc.)
Ms Lata Shamale (M.Sc.)
Ms Chhaya Kapadia (Ph.D.)
Ms Shamim Sheikh (Ph.D.)
Ms Rajbinder Kaur (Ph.D.)
Mr Deepak Modi (Ph.D.)
Mr Neeraj Kumar (Ph.D.)
Ms. Sreepoorna Unni (Ph.D.)
Ms Seema Parte (Ph.D.)
Mr Prasad Pethe (Thesis writing)

Woman Scientist (DST)

Dr Kalpana Sriraman (completed)

ICMR Post-Doctoral Fellow

Dr Jarnail Singh

 

Projects

Completed:

  • Isolation and propagation in vitro of VSELs from adult gonadal tissue and 3D maturation of germ cells. (Funded by Ministry of Science and Technology, Department of Biotechnology) 
  • Differentiation and characterization of cardiac progenitor cells and early cardiomyocytes derived from indigenously developed human embryonic stem cell lines. (Funded by Ministry of Science and Technology, Department of Biotechnology) 
  • Derivation of additional human embryonic stem cell lines from spare and discarded embryos and their characterization. (Funded by Ministry of Science and Technology, Department of Biotechnology) 
  • Lineage specific differentiation of human embryonic stem cells into insulin producing cells. (Funded by Ministry of Science and Technology, Department of Biotechnology) 
  • Development of non-human primate (Marmoset) ES cells as a regenerative source for cell therapy. (Funded by Ministry of Science and Technology, Department of Biotechnology)
  • To establish technologies of parthenogenesis and somatic cell nuclear transfer (SCNT) using sheep eggs.(Funded by Ministry of Science and Technology, Department of Biotechnology)
  • To establish human embryonic stem (hES) cell lines without mouse feeder (MEF) layers and study factors in MEF layer that prevent differentiation of hES cells in Vitro. (Funded by Ministry of Science and Technology, Department of Biotechnology )
  • To standardize protocols for cryopreservation of gonadal tissue and study follicle growth in SCID mice. (Funded by DST, Ministry of Science and Technology, New Delhi)

 Ongoing:

  • Preclinical studies using human ES cells derived cardio-vascular tripotent progenitors (Funded by ICMR, Department of Health Research)
  • Preclinical studies using human ES cells derived islet progenitors (Funded by ICMR, Department of Health Research)