Dr. Nafisa H. Balasinor



 

 

 

 







 

Scientist 'F'

Neuroendocrinology
Phone : +( 91-22) 2419 2025
Email  : balasinorn@nirrh.res.in

Academic Background

  • B.Sc. Sophia College University of Mumbai, 1980
  • M.Sc. Sophia College , University of Mumbai (Life Sciences, 1982)
  • Ph.D. Institute for Research in Reproduction, University of Bombay (Biochemistry, 1989)

Professional Experience

2015-till date 

National Institute for Research in Reproductive Health (NIRRH)

Scientist F

2010-2015

National Institute for Research in Reproductive Health (NIRRH)

Scientist E   

2006-2010

National Institute for Research in Reproductive Health (NIRRH)

Scientist D

2001-2006

National Institute for Research in Reproductive Health (NIRRH)

Scientist C

1996 - 2001

National Institute for Research in Reproductive Health (NIRRH)

Research Officer   

 


 

 

 

 

Research Interests

  • Reproductive Neuroendocrinology
  • Epigenetics

Awards & Achievements

  • Awarded Overseas Research Associateship from Department of Biotechnology for training under Prof. Rex Hess, Department of Veterinary Biosciences, University of Illinois, USA. 2002-2003
  • Prof. G. P. Talwar Middle Career Scientist Award received at theInternational Conference on Frontiers in Reproductive Biotechnology & 21 st Annual meeting of ISSRF, February 9-11 2011 at NDRI, Karnal, Haryana, in recognition of the outstanding contributions in the field of Reproductive Health
  • ICMR Smt. Swaran Kanta Dingley Oration Award - 2009
  • Receipient of ICMR Smt. Swaran Kanta Dingley Oration Award - 2009

Publications (Last 10)

    • Ankolkar M, Salvi V, Warke H, Vundinti BR, Balasinor NH. Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurrent spontaneous miscarriages. Fertil Steril. 99(6):1668-73, (2013).
    • Kedia-Mokashi NA, Kadam L, Ankolkar M, Dumasia K,  Balasinor NH. Aberrant methylation of multiple imprinted genes in embryos of tamoxifen-treated male rats. Reproduction. 146(2):155-68 , ( 2013 )
    • Upadhyay RD, Kumar AV, Sonawane S, Gaonkar R,  Balasinor NH. Estrogen effects on actin cytoskeletal and endocytic proteins associated with tubulobulbar complex disruption in rat testes. Reprod Sci. 10:1162-74 , (2013)
    • Upadhyay RD , Yadav AK, Sonawane S, Goankar R, Dash D, Balasinor NH . Differential Proteomic and Phospho-proteomic Analysis of Normal versus Failed Spermiation in Adult Rats by Label-Free LC-MS/MS. Journal of Analytical & Bioanalytical Techniques 4(4):1000172 , (2013)
    • Upadhyay RD, Kumar A, Balasinor NH., Localization of proteins involved in endocytosis at tubulobulbar complexes in rat testes. Advances in Reproductive Sciences  2: 1-7 (2014)
    •  Anita Kumar, Kushaan Dumasia, Reshma Gaonkar, Shobha Sonawane, Leena Kadam  and  NH. Balasinor; Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation. Molecular and Cellular Endocrinology 404: 91–101 (2015)
    • Dumasia K, Kumar A, Kadam L, Balasinor NH. Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats. J Endocrinol.225(3):169-80 ( 2015)
    • Dumasia K, Kumar A, Deshpande S, Sonawane S, Balasinor NH. Differential roles of estrogen receptors, ESR1 and ESR2, in adult rat spermatogenesis. Mol Cell Endocrinol. 428: 89-100.  (2016)
    • Ankolkar M, Balasinor NH. Endocrine control of epigenetic mechanisms in male reproduction. Horm Mol Biol Clin Investig. 2016 Jan 1;25(1):65-70.
    • Neelam Kedia, Leena Kadam, Kushaan Dumasia and Balasinor NH. Possible Role of Paternal Aberrant Imprinting in Placental Development: A Study in Tamoxifen Treatment Rat Model. Journal of Clinical Epigenetics 2: 1 (2016)

    Students

    • Kushan Dumasia
    • Anita Kumar
    • Sharvari Deshpande
    • Sweta Mohan

    Projects with funding agency

    Ongoing Research Projects

    S r No.

    Title of Project

    Funding Agency

    Date of Sanction and Duration

    1.

    Genetic and epigenetic changes in male partners of women experiencing recurrent spontaneous abortions

     

    DST, New Delhi

     

    2015-2018

    Completed Research Projects

    Sr No.

    Title of Project

    Funding Agency

    Date of Sanction and Duration

      1.

    Genomic imprinting : A paternal contribution to embryogenesis

    ICMR “Functional Genomics

      2002-2005

    2.

    Effect of estrogen/antiestrogen on germ cell maturation in the testis

    DBT, New Delhi under Indo-US CRHR

      2002-2005

    3.

    Teratological studies of an ayurvedic contraceptive: Pippaliyadi vati

      MHOFW

      2004-2005

    4.

    Role of imprinting cluster on rat chromosome 1 in embryogenesis

      DBT, New Delhi

      2006-2009

    5.

    Studies to elucidate estrogen mediated mechanism for gametic imprint mark at Igf2-H19 locus in the male germ line

    ICMR Innovation fund

    2007 –2010

    6.

    Characterization of placental defects in embryos following paternal tamoxifen treatment

      BRNS-DAE

      2010-2013

    7.

    Characterization of molecular events during spermiation

      DST, New Delhi

       2008 -2011

    8.

    Embryo loss due to epigenetic abnormalities in the male germ line: A study in recurrent spontaneous abortions

     
      DBT, New Delhi

     
       2010-2013

    9.

    Studies to elucidate molecular mechanism of estrogen action during spermiation

     
    DST, New Delhi

     

    2012-2016