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Scientist 'D'
Neuroendocrinology
Phone : +( 91-22) 2419 2025
Email : balasinorn@nirrh.res.in
Academic Background
- B.Sc. Sophia College University of Mumbai, 1980
- M.Sc. Sophia College , University of Mumbai
(Life Sciences, 1982)
- Ph.D. Institute for Research in Reproduction, University of Bombay (Biochemistry, 1989)
Professional Experience
| Scientist D |
National Institute for Research in Reproductive Health |
Since 2006 |
| Scientist C |
National Institute for Research in Reproductive Health |
2001 |
| Scientist B |
National Institute for Research in Reproductive Health |
1996 |
Research Interests
- Reproductive Neuroendocrinology
- Epigenetics
Awards & Achievements
- Awarded Overseas Research Associateship from Department of Biotechnology for training under Prof. Rex Hess, Department of Veterinary Biosciences, University of Illinois, USA. 2002-2003
- Prof. G. P. Talwar Middle Career Scientist Award received at theInternational Conference on Frontiers in Reproductive Biotechnology & 21 st Annual meeting of ISSRF, February 9-11 2011 at NDRI, Karnal, Haryana, in recognition of the outstanding contributions in the field of Reproductive Health
Publications (Last 10)
- Balasinor N , Parte P, Gill-Sharma MK, Kini J, Juneja HS Mechanism delineating differential effect of an antiestrogen, tamoxifen, on the serum LH and FSH in adult male rats. J Endocrinol Invest.; 29(6):485-96 (2006)
- Balasinor N , Bhan A, Paradkar N, Shaikh A, Nandedkar T, Bhutani K.K., Roy Chaudhury M. Post natal development and reproductive performance of F1 progeny exposed in-utero to an ayurvedic contraceptive: Pippaliyadi yoga. Journal of Ethnopharmacology ;109(3):406-11 (2007)
- Pathak S, Balasinor N. Epigenetic routes to haploidy in the male germ line. Invited paper; Proceedings of the National Academy of Sciences, India; vol 77, B, Special Issue, (2007)
- D'Souza R, Pathak S, Upadhyay R, Gaonkar R, D'Souza S, Sonawane S, Gill-Sharma M, Balasinor N. Disruption of Tubulobulbar Complex by High Intratesticular Estrogens Leading to Failed Spermiation. Endocrinology; 150: 1861 - 1869. (2009)
- Pathak S, Kedia-Mokashi N, Saxena M, D'Souza R, Maitra A, Parte P, Gill-Sharma M, Balasinor N. Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss. Fertility and Sterility, Volume 91 (Supplement): 2253-2263. (2009)
- Pathak S, D’Souza R, Ankolkar M, Gaonkar R, Balasinor NH. Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Molecular & Cellular Endocrinology 314: 110-7 (2010)
- Pathak S, Saxena M, D’Souza R and Balasinor NH. Disrupted imprinting status at the H19 differentially methylated region is associated with the resorbed embryo phenotype in rats. Reproduction Develop Fertility l 22 , 939–948 (2010)
- Balasinor NH , D’Souza R, Nanaware P, Idicula-Thomas S, Kedia-Mokashi N, He Z and Dym M Effect of high intratesticular estrogen on global gene expression and testicular cell number in rats. Reproductive Biology and Endocrinology, 8:72 (2010)
- Neelam Kedia-Mokashi, Aida E.L. Makawy, Madhurima Saxena and N.H. Balasinor. Chromosomal aberration in the post-implantation embryos sired by tamoxifen treated male rats. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 703 169–173, (2010)
- Kedia-Mokashi N, Mugasimagalam R, Aiyaz M, Mukherjee S, Balasinor N H. Aberrant expression of imprinted genes in post-implantation rat embryos. Life Sciences 88: 634–643, (2011)
Present students
- Neelam Mokashi
- R Upadhyay
- M Ankolkar
- Kushan Dumasia
- Anita Kumar
Past student
Projects with funding agency
Ongoing Research Projects
S r No. |
Title of Project |
Funding Agency |
Date of Sanction and Duration |
1. |
Characterization of placental defects in embryos following paternal tamoxifen treatment |
BRNS-DAE |
2010-2013 |
2. |
Characterization of molecular events during spermiation |
DST, New Delhi |
2008 -2011 |
3. |
Embryo loss due to epigenetic abnormalities in the male germ line: A study in recurrent spontaneous abortions |
DBT, New Delhi |
2010-2013 |
Completed Research Projects
Sr No. |
Title of Project |
Funding Agency |
Date of Sanction and Duration |
1. |
Genomic imprinting : A paternal contribution to embryogenesis |
ICMR “Functional Genomics |
2002-2005 |
2. |
Effect of estrogen/antiestrogen on germ cell maturation in the testis |
DBT, New Delhi under Indo-US CRHR |
2002-2005 |
3. |
Teratological studies of an ayurvedic contraceptive: Pippaliyadi vati |
MHOFW |
2004-2005 |
4. |
Role of imprinting cluster on rat chromosome 1 in embryogenesis |
DBT, New Delhi |
2006-2009 |
5. |
Studies to elucidate estrogen mediated mechanism for gametic imprint mark at Igf2-H19 locus in the male germ line |
ICMR Innovation fund |
2007 –2010 |
6. |
Molecular mechanism underlying nuclear chromatin condensation: Differential regulation by testosterone and FSH |
DST , New Delhi
|
2008-2011 |
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