Dr. Taruna Madan
Scientist-F
Email: taruna_m[at]hotmail[dot]com, guptat[at]nirrh[dot]res[dot]in
Phone: +( 91-22) 24192049
Department: Innate Immunity
Academic Background
- B.Pharm University of Delhi College of Pharmacy, 1989
- M.Pharm University of Delhi College of Pharmacy, 1991
- Ph.D University of Delhi College of Pharmacy, and Institute of Genomics and Integrative Biology, 1999
Professional Experience
| Scientist E-I | Institute of Genomics and Integrative Biology, Delhi |
2005-2007
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| Scientist C | Institute of Genomics and Integrative Biology, Delhi |
2002-2005
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| Visiting scientist | MRC Immunochemistry Unit, Oxford |
June- September, 2000
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| Senior Research Associate | Institute of Genomics and Integrative Biology, Delhi |
1999-2002
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| Research Associate | Institute of Genomics and Integrative Biology, Delhi |
Research Interests
- Innate immunity in host defense against infections and malignancy for prevention, diagnosis and therapy of human disease
- Evaluation of innate immune molecules as microbicides for prevention of STIs including HIV
- Role of collectins, innate immune molecules, in uterine biology, pregnancy maintenance and immunoprivilege of testis
- Aspergillosis : diagnosis, pathogenesis and therapy
Present
- Ms. Kavita A. Kale, PhD Scholar
- Ms. Gargi Thakur, PhD Scholar
- Ms. Aishwarya Rao, PhD Scholar
- Ms. Kasturi Ganguly, PhD Scholar
Past
- Dr. Savneet Kaur
- Dr. Jata Shankar
- Dr. NeelKamal
- Dr. Poonam Gautam
- Dr. Mudit Vaid
- Dr. Lakshna Mahajan
- Dr. Santosh Upadhyay
- Dr. Ajit Kumar Yadav
- Dr. Aghila KG Rani
- Dr. Hrishikesh Pandit
- Dr. Sharon Kay
- Dr. Sushma Rokade
Awards & Achievements
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Young Women Bioscientist, 2004, by Indian Science Congress, Chandigarh
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CSIR Young Scientist, Life Sciences, 2003 for work on identification of role of lung surfactant proteins A and D in host defense against aspergillosis.
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Charles Richets Prize, 2000 for the outstanding contributions on “Aspergillosis” in the area of Allergy, Asthma and Clinical Immunology, conferred by Indian College of Allergy, Asthma and Applied Immunology.
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INSA Young Scientist Medal (Medical Sciences, 1998) for “Immunopathogenesis of Aspergillosis”.
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Indian Pharmaceutical Association Silver Medal for Ist position in M.Pharm. in 1992.
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G.P.Nair Award and K.K.Acharjee Fellowship by Indian Drug Manufacturers Association Bombay and University of Delhi for Ist position in B.Pharm. in Delhi University in 1990.
Publications
1: Pandit H, Kale K, Yamamoto H, Thakur G, Rokade S, Chakraborty P, Vasudevan M, Kishore U, Madan T and Fichorova RN. Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier. Front Immunol. 2019, Mar 28;10:264.
2: Shende R, Wong SSW, Rapole S, Beau R, Ibrahim-Granet O, Monod M, Gührs KH, Pal JK, Latgé JP, Madan T, Aimanianda V, Sahu A. Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins. J Biol Chem. 2018 Oct 5;293(40):15538-15555.
3: Kumar A, Banerjee A, Singh D, Thakur G, Kasarpalkar N, Gavali S, Gadkar S, Madan T, Mahale SD, Balasinor NH, Sachdeva G. Estradiol: A Steroid with Multiple Facets. Horm Metab Res. 2018 Mar 22.
4: Waghu FH, Joseph S, Ghawali S, Martis EA, Madan T, Venkatesh KV, Idicula-Thomas S. Designing Antibacterial Peptides with Enhanced Killing Kinetics. Front Microbiol. 2018 Feb 23;9:325.
5: Sze Wah Wong S, Rani M, Dodagatta-Marri E, Ibrahim-Granet O, Kishore U, Bayry J, Latgé JP, Sahu A, Madan T, Aimanianda V. Fungal melanin stimulates surfactant protein D-mediated opsonization of and host immune response to Aspergillus fumigatus spores. J Biol Chem. 2018 Feb 5. pii: jbc.M117.815852.
6: Madan T. Recombinant Fragment of Human Surfactant Protein D: A Hierarchical Regulator of Pulmonary Hypersensitivity. Am J Respir Crit Care Med. 2017 Dec15;196(12):1495-1496.
7: Dodagatta-Marri E, Mitchell DA, Pandit H, Sonawani A, Murugaiah V, Idicula-Thomas S, Nal B, Al-Mozaini MM, Kaur A, Madan T, Kishore U. Protein-Protein Interaction between Surfactant Protein D and DC-SIGN via C-Type Lectin Domain Can Suppress HIV-1 Transfer. Front Immunol. 2017 Jul 31;8:834.
8: Pednekar L, Pandit H, Paudyal B, Kaur A, Al-Mozaini MA, Kouser L, Ghebrehiwet B, Mitchell DA, Madan T, Kishore U. Complement Protein C1q Interacts with DC-SIGN via Its Globular Domain and Thus May Interfere with HIV-1 Transmission. Front Immunol. 2016 Dec 22;7:600.
9: Rokade S, Kishore U, Madan T. Surfactant protein D regulates murine testicular immune milieu and sperm functions. Am J Reprod Immunol. 2017 Mar;77(3).
10: Koippallil Gopalakrishnan AR, Kishore U, Madan T. Mesenchymal stem cells: a promising tool for targeted gene therapy of endometriosis. Regen Med. 2017 Jan;12(1):69-76. doi: 10.2217/rme-2016-0084.
11: Madhukaran SP, Alhamlan FS, Kale K, Vatish M, Madan T, Kishore U. Role of collectins and complement protein C1q in pregnancy and parturition. Immunobiology. 2016 Nov;221(11):1273-88.
12: Rokade S, Madan T. Testicular expression of SP-A, SP-D and MBL-A is positively regulated by testosterone and modulated by lipopolysaccharide. Immunobiology. 2016 Sep;221(9):975-85.
13: Bhetariya PJ, Prajapati M, Bhaduri A, Mandal RS, Varma A, Madan T, Singh Y, Sarma PU. Phylogenetic and Structural Analysis of Polyketide Synthases in Aspergilli. Evol Bioinform Online. 2016 May 10;12:109-19.
14: Koippallil Gopalakrishnan AR, Pandit H, Metkari SM, Warty N, Madan T. Adenoviral vector encoding soluble Flt-1 engineered human endometrial mesenchymal stem cells effectively regress endometriotic lesions in NOD/SCID mice. Gene Ther. 2016 Jul;23(7):580-91.
15: Kay S, Madan T. Fertility defects in Surfactant associated protein D knockout female mice: altered ovarian hormone profile. Mol Immunol. 2016 Mar;71:87-97.
16: Gautam P, Mushahary D, Hassan W, Upadhyay SK, Madan T, Sirdeshmukh R, Sundaram CS, Sarma PU. In-depth 2-DE reference map of Aspergillus fumigatus and its proteomic profiling on exposure to itraconazole. Med Mycol. 2016 Jul 1;54(5):524-36.
17: Singh M, Mahajan L, Chaudhary N, Kaur S, Madan T, Sarma PU. Murine models of Aspergillosis: Role of collectins in host defense. Indian J Exp Biol. 2015 Nov;53(11):691-700.
18: Yadav AK, Chaudhari H, Shah PK, Madan T. Expression and localization of collectins in feto-maternal tissues of human first trimester spontaneous abortion and abortion prone mouse model. Immunobiology. 2016 Feb;221(2):260-8.
19: Pandit H, Thakur G, Koippallil Gopalakrishnan AR, Dodagatta-Marri E, Patil A, Kishore U, Madan T. Surfactant protein D induces immune quiescence and apoptosis of mitogen-activated peripheral blood mononuclear cells. Immunobiology. 2016 Feb;221(2):310-22.
20: Madhukaran SP, Koippallil Gopalakrishnan AR, Pandit H, Marri ED, Kouser L, Jamil K, Alhamlan FS, Kishore U, Madan T. Expression of surfactant proteins SP-A and SP-D in murine decidua and immunomodulatory effects on decidual macrophages. Immunobiology. 2016 Feb;221(2):377-86.
21: Kay S, Metkari SM, Madan T. Ovarian Hormones Regulate SP-D Expression in the Mouse Uterus During Estrous Cycle and Early Pregnancy. Am J Reprod Immunol. 2015 Jul;74(1):77-88.
22: Koippallil Gopalakrishnan Nair AR, Pandit H, Warty N, Madan T. Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype. Int Immunol. 2015 Apr;27(4):195-204.
23: Yadav AK, Chaudhari H, Warke H, Shah PK, Dodagatta-Marri E, Kishore U, Madan T. Differential expression of collectins in human placenta and role in inflammation during spontaneous labor. PLoS One. 2014 Oct 10;9(10):e108815.
24: Pandit H, Gopal S, Sonawani A, Yadav AK, Qaseem AS, Warke H, Patil A, Gajbhiye R, Kulkarni V, Al-Mozaini MA, Idicula-Thomas S, Kishore U, Madan T. Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production. PLoS One. 2014 Jul 18;9(7):e102395.
25: Mahajan L, Gautam P, Dodagatta-Marri E, Madan T, Kishore U. Surfactant protein SP-D modulates activity of immune cells: proteomic profiling of its interaction with eosinophilic cells. Expert Rev Proteomics. 2014 Jun;11(3):355-69.
26: Mahajan L, Pandit H, Madan T, Gautam P, Yadav AK, Warke H, Sundaram CS, Sirdeshmukh R, Sarma PU, Kishore U, Surolia A. Human surfactant protein D alters oxidative stress and HMGA1 expression to induce p53 apoptotic pathway in eosinophil leukemic cell line. PLoS One. 2013 Dec 31;8(12):e85046.
27: Dodagatta-Marri E, Qaseem AS, Karbani N, Tsolaki AG, Waters P, Madan T, Kishore U. Purification of surfactant protein D (SP-D) from pooled amniotic fluid and bronchoalveolar lavage. Methods Mol Biol. 2014;1100:273-90.
28: Karbani N, Dodagatta-Marri E, Qaseem AS, Madhukaran P, Waters P, Tsolaki AG, Madan T, Kishore U. Purification of native surfactant protein SP-A from pooled amniotic fluid and bronchoalveolar lavage. Methods Mol Biol. 2014;1100:257-72.
29: Agarwal R, Chakrabarti A, Shah A, Gupta D, Meis JF, Guleria R, Moss R, Denning DW; ABPA complicating asthma ISHAM working group. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013 Aug;43(8):850-73.
30: Qaseem AS, Sonar S, Mahajan L, Madan T, Sorensen GL, Shamji MH, Kishore U. Linking surfactant protein SP-D and IL-13: implications in asthma and allergy.Mol Immunol. 2013 May;54(1):98-107.
31: Goswami R, Singh A, Gupta N; Indian Genome Variation Consortium, Rani R.Presence of strong association of the major histocompatibility complex (MHC) class I allele HLA-A*26:01 with idiopathic hypoparathyroidism. J Clin Endocrinol Metab. 2012 Sep;97(9):E1820-4.
32: Bhetariya PJ, Madan T, Basir SF, Varma A, Usha SP. Allergens/Antigens, toxins and polyketides of important Aspergillus species. Indian J Clin Biochem. 2011 Apr;26(2):104-19. doi: 10.1007/s12291-011-0131-5.
33: Pandit H, Madhukaran SP, Nayak A, Madan T. SP-A and SP-D in host defense against fungal infections and allergies. Front Biosci (Elite Ed). 2012 Jan 1;4:651-61.
34: Upadhyay SK, Gautam P, Pandit H, Singh Y, Basir SF, Madan T. Identification of fibrinogen-binding proteins of Aspergillus fumigatus using proteomic approach. Mycopathologia. 2012 Mar;173(2-3):73-82..
35: Gautam P, Upadhyay SK, Hassan W, Madan T, Sirdeshmukh R, Sundaram CS, Gade WN, Basir SF, Singh Y, Sarma PU. Transcriptomic and proteomic profile of Aspergillus fumigatus on exposure to artemisinin. Mycopathologia. 2011 Nov;172(5):331-46.
36: Yadav AK, Madan T, Bernal AL. Surfactant proteins A and D in pregnancy and parturition. Front Biosci (Elite Ed). 2011 Jan 1;3:291-300.
37: Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, Ghosh S, Agrawal A; Indian Genome Variation Consortium, Prasher B, Mukerji M. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18961-6.
38: Madan T, Reid KB, Clark H, Singh M, Nayak A, Sarma PU, Hawgood S, Kishore U. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis. Mol Immunol. 2010 Jun;47(10):1923-30.
39: Chaudhary N, Mahajan L, Madan T, Kumar A, Raghava GP, Katti SB, Haq W, Sarma PU. Prophylactic and Therapeutic Potential of Asp f1 Epitopes in Naïve and Sensitized BALB/c Mice. Immune Netw. 2009 Oct;9(5):179-91.
40: Waters P, Vaid M, Kishore U, Madan T. Lung surfactant proteins A and D as pattern recognition proteins. Adv Exp Med Biol. 2009;653:74-97.
41: Upadhyay SK, Mahajan L, Ramjee S, Singh Y, Basir SF, Madan T. Identification and characterization of a laminin-binding protein of Aspergillus fumigatus: extracellular thaumatin domain protein (AfCalAp). J Med Microbiol. 2009 Jun;58(Pt 6):714-22.
42: Singh M, Madan T, Waters P, Sonar S, Singh SK, Kamran MF, Bernal AL, Sarma PU, Singh VK, Crouch EC, Kishore U. Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis. Mol Immunol. 2009 Jul;46(11-12):2363-9.
43: Upadhyay SK, Shankar J, Singh Y, Basir SF, Madan T, Sarma PU. Expressed sequence tags of Aspergillus fumigatus: Extension of catalogue and their evaluation as putative drug targets and/or diagnostic markers. Indian J Clin Biochem. 2009 Apr;24(2):131-6. doi: 10.1007/s12291-009-0024-z.
44: Gautam P, Shankar J, Madan T, Sirdeshmukh R, Sundaram CS, Gade WN, Basir SF, Sarma PU. Proteomic and transcriptomic analysis of Aspergillus fumigatus on exposure to amphotericin B. Antimicrob Agents Chemother. 2008 Dec;52(12):4220-7.
45: Mahajan L, Madan T, Kamal N, Singh VK, Sim RB, Telang SD, Ramchand CN, Waters P, Kishore U, Sarma PU. Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages. Int Immunol. 2008 Aug;20(8):993-1007.
46: Indian Genome Variation Consortium. Genetic landscape of the people of India:a canvas for disease gene exploration. J Genet. 2008 Apr;87(1):3-20.
47: Bhatnagar S, Bhattacharjee J, Vaid M, Madan T, Trivedi SS, Sarma PU. Inducible nitric oxide synthase (iNOS) gene polymorphism in pre-eclampsia: a pilot study in North India. Aust N Z J Obstet Gynaecol. 2007 Dec;47(6):477-82.
48: Gautam P, Sundaram CS, Madan T, Gade WN, Shah A, Sirdeshmukh R, Sarma PU. Identification of novel allergens of Aspergillus fumigatus using immunoproteomics approach. Clin Exp Allergy. 2007 Aug;37(8):1239-49.
49: Kaur S, Gupta VK, Thiel S, Sarma PU, Madan T. Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. Clin Exp Immunol. 2007 May;148(2):382-9.
50: Vaid M, Kaur S, Sambatakou H, Madan T, Denning DW, Sarma PU. Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Clin Chem Lab Med. 2007;45(2):183-6.
51: Madan T. Potential of lung surfactant proteins, SP-A and SP-D, and mannan binding lectin for therapy and genetic predisposition to allergic and invasive aspergillosis. Recent Pat Inflamm Allergy Drug Discov. 2007 Nov;1(3):183-7.
52: Gautam P, Madan T, Gade WN, Sarma PU. Immunoproteomic analysis of secretory proteins of Aspergillus fumigatus with specific IgE immunoreactivity. Indian J Clin Biochem. 2006 Sep;21(2):12-9.
53: Kaur S, Thiel S, Sarma PU, Madan T. Mannan-binding lectin in asthma and allergy. Curr Allergy Asthma Rep. 2006 Sep;6(5):377-83.
54: Kaur S, Gupta VK, Shah A, Thiel S, Sarma PU, Madan T. Elevated levels of mannan-binding lectin [corrected] (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL. Clin Exp Immunol. 2006 Mar;143(3):414-9.
55: Kaur S, Gupta VK, Shah A, Thiel S, Sarma PU, Madan T. Plasma mannan-binding lectin levels and activity are increased in allergic patients. J Allergy Clin Immunol. 2005 Dec;116(6):1381-3.
56: Kamal N, Chowdhury S, Madan T, Sharma D, Attreyi M, Haq W, Katti SB, Kumar A, Sarma PU. Tryptophan residue is essential for immunoreactivity of a diagnostically relevant peptide epitope of A. fumigatus. Mol Cell Biochem. 2005 Jul;275(1-2):223-31.
57: Kishore U, Bernal AL, Kamran MF, Saxena S, Singh M, Sarma PU, Madan T, Chakraborty T. Surfactant proteins SP-A and SP-D in human health and disease. Arch Immunol Ther Exp (Warsz). 2005 Sep-Oct;53(5):399-417.
58: Kishore U, Greenhough TJ, Waters P, Shrive AK, Ghai R, Kamran MF, Bernal AL, Reid KB, Madan T, Chakraborty T. Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol Immunol. 2006 Mar;43(9):1293-315.
59: Saxena S, Kumar R, Madan T, Gupta V, Muralidhar K, Sarma PU. Association of polymorphisms in pulmonary surfactant protein A1 and A2 genes with high-altitude pulmonary edema. Chest. 2005 Sep;128(3):1611-9.
60: Madan T, Kaur S, Saxena S, Singh M, Kishore U, Thiel S, Reid KB, Sarma PU. Role of collectins in innate immunity against aspergillosis. Med Mycol. 2005 May;43 Suppl 1:S155-63.
61: Madan T, Reid KB, Singh M, Sarma PU, Kishore U. Susceptibility of mice genetically deficient in the surfactant protein (SP)-A or SP-D gene to pulmonary hypersensitivity induced by antigens and allergens of Aspergillus fumigatus. J Immunol. 2005 Jun 1;174(11):6943-54.
62: Maurya V, Gugnani HC, Sarma PU, Madan T, Shah A. Sensitization to Aspergillus antigens and occurrence of allergic bronchopulmonary aspergillosis in patients with asthma. Chest. 2005 Apr;127(4):1252-9.
63: Shankar J, Madan T, Basir SF, Sarma PU. Identification and characterization of polyubiquitin gene from cDNA library of aspergillus fumigatus. Indian J Clin Biochem. 2005 Jan;20(1):208-12.
64: Shankar J, Nigam S, Saxena S, Madan T, Sarma PU. Identification and assignment of function to the genes of Aspergillus fumigatus expressed at 37degrees C. J Eukaryot Microbiol. 2004 Jul-Aug;51(4):428-32.
65: Madan T, Priyadarsiny P, Vaid M, Kamal N, Shah A, Haq W, Katti SB, Sarma PU. Use of a synthetic peptide epitope of Asp f 1, a major allergen or antigen of Aspergillus fumigatus, for improved immunodiagnosis of allergic bronchopulmonary aspergillosis. Clin Diagn Lab Immunol. 2004 May;11(3):552-8.
66: Saxena S, Madan T, Muralidhar K, Sarma PU. cDNA cloning, expression and characterization of an allergenic L3 ribosomal protein of Aspergillus fumigatus. Clin Exp Immunol. 2003 Oct;134(1):86-91.
67: Sarma UP, Kurup VP, Madan T. Immunodiagnosis of ABPA. Front Biosci. 2003 Sep 1;8:s1187-98.
68: Dembinska-Kiec A, Madan T, Batt AM, Vincent-Viry M, Schmitz G, Van Helden PD, Poulis P, Walter JE, Naskalski J, Loukopoulos D, Baranova H. Ethical issues: should we give the predictive genetic profile to the citizens? Clin Chem Lab Med. 2003 Apr;41(4):559-63.
69: Masana L, Madan T, Visvikis S, Sass C, Baranova H, Bonnet J, Dembinska A, Ehrlich H, Gueyffier F, Schmitz G, Siest G, Zannis V. Which, and how limited number of polymorphisms should be selected per disease, risk assessment, health profile or biological system? Clin Chem Lab Med. 2003 Apr;41(4):554-8.
70: Saxena S, Madan T, Shah A, Muralidhar K, Sarma PU. Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol. 2003 May;111(5):1001-7.
71: Singh M, Madan T, Waters P, Parida SK, Sarma PU, Kishore U. Protective effects of a recombinant fragment of human surfactant protein D in a murine model of pulmonary hypersensitivity induced by dust mite allergens. Immunol Lett. 2003 May 1;86(3):299-307.
72: Madan T, Saxena S, Murthy KJ, Muralidhar K, Sarma PU. Association of polymorphisms in the collagen region of human SP-A1 and SP-A2 genes with pulmonary tuberculosis in Indian population. Clin Chem Lab Med. 2002 Oct;40(10):1002-8.
73: Kishore U, Madan T, Sarma PU, Singh M, Urban BC, Reid KB. Protective roles of pulmonary surfactant proteins, SP-A and SP-D, against lung allergy and infection caused by Aspergillus fumigatus. Immunobiology. 2002 Sep;205(4-5):610-8.
74: Madan T, Kishore U, Singh M, Strong P, Hussain EM, Reid KB, Sarma PU. Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis. Infect Immun. 2001 Apr;69(4):2728-31.
75: Madan T, Kishore U, Singh M, Strong P, Clark H, Hussain EM, Reid KB, Sarma PU. Surfactant proteins A and D protect mice against pulmonary hypersensitivity induced by Aspergillus fumigatus antigens and allergens. J Clin Invest. 2001 Feb;107(4):467-75.
76: Sarma PU, Sarma PV, Madan T. Challenges in prevention, diagnosis and therapy of emerging fungal diseases. Aspergillosis: A case study. Indian J Clin Biochem. 2000 Aug;15(Suppl 1):43-50.
77: Purkayastha S, Madan T, Shah A, Krishnamurthy HG, Sarma PU. Multifunctional antigens of A. fumigatus and specific antibodies. Appl Biochem Biotechnol. 2000 Jan-Mar;83(1-3):271-83; discussion 283-6, 297-313.
78: Sarma PV, Purkayastha S, Madan T, Sarma PU. Expression of an epitopic region of AspfI, an allergen/antigen/cytotoxin of Aspergillus fumigatus. Immunol Lett.1999 Dec 1;70(3):151-5.
79: Madan T, Kishore U, Shah A, Eggleton P, Strong P, Wang JY, Aggrawal SS, Sarma PU, Reid KB. Lung surfactant proteins A and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils. Clin Exp Immunol. 1997 Nov;110(2):241-9.
80: Madan T, Arora N, Sarma PU. Ribonuclease activity dependent cytotoxicity of Asp fl, a major allergen of A. fumigatus. Mol Cell Biochem. 1997 Oct;175(1-2):21-7.
81: Madan T, Eggleton P, Kishore U, Strong P, Aggrawal SS, Sarma PU, Reid KB. Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect Immun. 1997 Aug;65(8):3171-9.
82: Madan T, Arora N, Sarma PU. Identification and evaluation of a major cytotoxin of A. fumigatus. Mol Cell Biochem. 1997 Feb;167(1-2):89-97.
83: Madan T, Banerjee B, Bhatnagar PK, Shah A, Sarma PU. Identification of 45 kD antigen in immune complexes of patients of allergic bronchopulmonary aspergillosis. Mol Cell Biochem. 1997 Jan;166(1-2):111-6.
84: Bhatnagar PK, Chattopadhya D, Sharma GL, Madan T, Sarma PU. Aspergillus fumigatus specific antibodies in multitransfused children with human immunodeficiency virus (HIV) infection in relation to serum levels of Interleukin-2, gamma Interferon and tumour necrosis factor. J Trop Pediatr. 1996 Apr;42(2):85-90. PubMed PMID: 8984220.
Projects Ongoing
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Studies to understand the tertiary structure-dependence on antimicrobial activity of 2 novel peptides (Co-I, Funded by Department of Science and Technology)
- Proteomics of medically important fungus Aspergillus fumigatus to identify potential allergens/ antigens, virulent factors and proteins and pathways involved in drug resistance (Funded by Department of Science and Technology)
- Task Force on Infectious disease Handling, Storage and Research Facilities [COR0011] (Funded by Council of Scientific and Industrial Research)
- Task Force on Identification of potential drug targets [SMM003] (Funded by Council of Scientific and Industrial Research (CSIR)
- Task Force on “Asthmatic & Allergic Disorders Mitigation mission” TFBG (Funded by Council of Scientific and Industrial Research)
- Molecular Mechanisms of host-pathogen interactions : Role of lung surfactant proteins in genetic predisposition to respiratory infectious diseases GAP0008 (Funded by Indian National Science Academy Young Scientist Project)