Dr. Taruna Gupta
Scientist-F
Email: taruna_m[at]hotmail[dot]com, guptat[at]nirrh[dot]res[dot]in
Phone: +( 91-22) 24192049
Department: Innate Immunity
Academic Background
- B.Pharm University of Delhi College of Pharmacy, 1989
- M.Pharm University of Delhi College of Pharmacy, 1991
- Ph.D University of Delhi College of Pharmacy, and Institute of Genomics and Integrative Biology, 1999
Professional Experience
| Scientist E-I | Institute of Genomics and Integrative Biology, Delhi |
2005-2007
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| Scientist C | Institute of Genomics and Integrative Biology, Delhi |
2002-2005
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| Visiting scientist | MRC Immunochemistry Unit, Oxford |
June- September, 2000
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| Senior Research Associate | Institute of Genomics and Integrative Biology, Delhi |
1999-2002
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| Research Associate | Institute of Genomics and Integrative Biology, Delhi |
Research Interests
- Innate immunity in host defense against infections and malignancy for prevention, diagnosis and therapy of human disease
- Evaluation of innate immune molecules as microbicides for prevention of STIs including HIV
- Role of collectins, innate immune molecules, in uterine biology, pregnancy maintenance and immunoprivilege of testis
- Aspergillosis : diagnosis, pathogenesis and therapy
Present
- Ms Sushama Rokade
- Ms. Kavita A. Kale
- Ms. Gargi Thakur
- Ms. Diksha Sharma
Past
- Ms Savneet Kaur
- Mr.Jata Shankar
- Ms NeelKamal
- Ms Poonam Gautam
- Mr.Mudit Vaid
- Ms Lakshna Mahajan
- Mr. Santosh Upadhyay
- Mr. Ajit Kumar Yadav
- Mr. Hrishikesh Pandit
- Ms Sharon Kay
Awards & Achievements
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Young Women Bioscientist, 2004, by Indian Science Congress, Chandigarh
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CSIR Young Scientist, Life Sciences, 2003 for work on identification of role of lung surfactant proteins A and D in host defense against aspergillosis.
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Charles Richets Prize, 2000 for the outstanding contributions on “Aspergillosis” in the area of Allergy, Asthma and Clinical Immunology, conferred by Indian College of Allergy, Asthma and Applied Immunology.
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INSA Young Scientist Medal (Medical Sciences, 1998) for “Immunopathogenesis of Aspergillosis”.
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Indian Pharmaceutical Association Silver Medal for Ist position in M.Pharm. in 1992.
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G.P.Nair Award and K.K.Acharjee Fellowship by Indian Drug Manufacturers Association Bombay and University of Delhi for Ist position in B.Pharm. in Delhi University in 1990.
Publications
Estradiol: A Steroid with Multiple Facets.
2018
Kumar A, Banerjee A, Singh D, Thakur G, Kasarpalkar N, Gavali S, Gadkar S, Madan T, Mahale SD, Balasinor NH, Sachdeva G.
Horm Metab Res.
Designing Antibacterial Peptides with Enhanced Killing Kinetics.
2018
Waghu FH, Joseph S, Ghawali S, Martis EA, Madan T, Venkatesh KV, Idicula-Thomas S.
Front Microbiol. doi: 10.3389/fmicb.2018.00325, 2018
Protein-Protein interaction between surfactant protein D and DC-SIGN via C-type lectin domain can suppress HIV-1 transfer.
2017
Dodagatta-Marri E, Mitchell DA, Pandit H, Sonawani A, Murugaiah V, Idicula-Thomas S, Nal B, Al-Mozaini MM, Kaur A, Madan T, Kishore U.
Front Immunol 31: 8:834, doi: 10.3389/fimmu.2017.00834, 2017.
Recombinant fragment of human Surfactant Protein D: A hierarchical regulator of pulmonary hypersensitivity.
2017
Madan T.
Am J Respir Crit Care Med 196:1495-1496, 2017
Fertility defects in Surfactant associated protein D knockout female mice: altered ovarian hormone profile
2016
Kay S, Madan T
Mol Immunol; 71:87-97,
Adenoviral vector encoding soluble Flt-1 engineered human endometrial mesenchymal stem cells effectively regress endometriotic lesions in NOD/SCID mice
2016
Koippallil Gopalakrishnan AR, Pandit H, Metkari SM, Warty N, Madan T
Gene Therapy Mar-18, 2016
Surfactant protein D induces immune quiescence and apoptosis of mitogen-activated peripheral blood mononuclear cells
2016
Pandit H, Thakur G, Koippallil Gopalakrishnan AR, Dodagatta-Marri E, Patil A, Kishore U, Madan T
Immunobiology 221: 310-22, 2016
Expression and localization of collectins in feto-maternal tissues of human first trimester spontaneous abortion and abortion prone mouse model
2016
Yadav AK, Chaudhari H, Shah PK, Madan T
Immunobiology; 221(2):260-8, 2016
In-depth 2-DE reference map of Aspergillus fumigatus and its proteomic profiling on exposure to itraconazole
2016
Gautam P, Mushahary D, Hassan W, Upadhyay SK, Madan T, Sirdeshmukh R, Sundaram CS, Sarma PU
Med Mycol, 2016
Expression of surfactant proteins SP-A and SP-D in murine decidua and immunomodulatory effects on decidual macrophages
2016
Madhukaran SP, Koippallil Gopalakrishnan AR, Pandit H, Marri ED, Kouser L, Jamil K, Alhamlan FS, Kishore U, Madan T
Immunobiology 221: 377-86, 2016
Mesenchymal stem cells: a promising tool for targeted gene therapy of Endometriosis.
2016
Koippallil Gopalakrishnan AR, Kishore U, Madan T.
Regenerative Medicine 12:69-76, 2016.
Role of collectins and complement protein C1q in pregnancy and parturition.
2016
Madhukaran SP, Alhamlan FS, Kale K, Vatish M, Madan T, Kishore U.
Immunobiology 221: 1273-88, 2016.
Complement protein C1q interacts with DC-SIGN via its globular domain and interferes with HIV-1 transmission.
2016
60. Pednekar L, Pandit H, Paudyal B, Ahmed Al-Mozaini M, Kouser L, Ghebrehiwet B, Anthony Mitchell D, Madan T, Kishore U.
Frontiers in Immunology 22:7: 600, 2016
Surfactant protein D regulates testicular immune milieu and sperm functions.
2016
Rokade S, Kishore U and Madan T.
Am J Reproduct Immunol 73, 2016.
Testicular expression of SP-A, SP-D and MBL-A is positively regulated by testosterone and modulated by lipopolysaccharide.
2016
Rokade S, Madan T.
Immunobiology 221:975-85, 2016.
Ovarian Hormones Regulate SP-D Expression in the Mouse Uterus during Estrous Cycle and Early Pregnancy
2015
Kay S, Metkari SM, Madan T
Am J Reprod Immunol 74: 77-88, 2015
Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype
2015
Koippallil Gopalakrishnan Nair AR, Pandit H, Warty N, Madan T
Int Immunol 27:195-204, 2015
Expression of surfactant proteins SP-A and SP-D in murine decidua and immunomodulatory effects on decidual macrophages
2015
Madhukaran SP, Koippallil Gopalakrishnan AR, Pandit H, Marri ED, Kouser L, Jamil K, Alhamlan FS, Kishore U, Madan T
Immunobiology 2015
Surfactant protein D induces immune quiescence and apoptosis of mitogen-activated peripheral blood mononuclear cells
2015
Pandit H, Thakur G, Koippallil Gopalakrishnan AR, Dodagatta-Marri E, Patil A, Kishore U, Madan T
Immunobiology 2015 Oct 28
Expression and localization of collectins in feto-maternal tissues of human first trimester spontaneous abortion and abortion prone mouse model
2015
Yadav AK, Chaudhari H, Shah PK, Madan T
Immunobiology 2015
Murine models of Aspergillosis: Role of collectins in host defense
2015
Singh M, Mahajan L, Chaudhary N, Kaur S, Madan T, Sarma PU
Indian J Exp Biol53(11):691-700, 2015
Endometriotic mesenchymal stem cells exhibit distinct immune-phenotype
2014
K G AR, Pandit H, Warty N and Madan T
Int Immunol Nov 21
Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production
2014
Pandit H, Gopal S, Sonawani A, Yadav AK, Qaseem AS, Warke H, Patil A, Gajbhiye, R, Kulkarni V, Al-Mozaini MA, Idicula-Thomas S, Kishore U and Madan T
PLoS One 9(7):e102395, 2014
Purification of surfactant protein D (SP-D) from pooled amniotic fluid and bronchoalveolar lavage
2014
Dodagatta-Marri E, Qaseem AS, Karbani N, Tsolaki AG, Waters P, Madan T and Kishore U
Meth Mol Biol 1100:273-90, 2014
Purification of native surfactant protein SP-A from pooled amniotic fluid and bronchoalveolar lavage
2014
Karbani N, Dodagatta-Marri E, Qaseem AS, Madhukaran P, Waters P, Tsolaki AG, Madan T and Kishore U
Meth Mol Biol 1100:257-72, 2014
Surfactant protein SP-D modulates activity of immune cells: proteomic profiling of its interaction with eosinophilic cells
2014
Mahajan L, Gautam P, Dodagatta-Marri E, Madan T and Kishore U
Expert Rev Proteomics 11:355-69, 2014
Human surfactant protein D alters oxidative stress and HMGA1 expression to induce p53 apoptotic pathway in eosinophil leukemic cell line
2013
Mahajan L, Pandit H, Madan T, Gautam P, Yadav AK, Warke H, Sundaram CS, Sirdeshmukh R, Sarma PU, Kishore U, Surolia A
PLoS One 8:e85046, 2013
Linking surfactant protein SP-D and IL-13: Implications in asthma and allergy
2013
Qaseem AS, Sonar S, Mahajan L, Madan T, Sorensen GL, Shamji MH, Kishore U
Mol Immunol 54:98-107, 2013
SP-A and SP-D in host defense against fungal infections and allergies
2012
Pandit H, Madhukaran SP, Nayak A, Madan T
Front Biosci (Elite Ed) Review 4, 651-661, 2012
Identification of fibrinogen-binding proteins of aspergillus fumigatus using proteomic approach
2012
Upadhyay SK, Gautam P, Pandit H, Singh Y, Basir SF, Madan T
Mycopathologia 173:73-82, 2012
Surfactant proteins A and D in pregnancy and parturition
2011
Yadav AK, Madan T, Bernal AL
Front Biosci (Elite Ed)
Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis
2010
Madan T, Reid KB, Clark H, Singh M, Nayak A, Sarma PU, Hawgood S, Kishore U
Mol Immunol 47: 1923-1930, 2010
Prophylactic and Therapeutic Potential of Asp f1 Epitopes in Naïve and Sensitized BALB/c Mice
2009
Chaudhary N, Mahajan L, Madan T, Kumar A, Raghava GP, Katti SB, Haq W, Sarma PU
Immune Netw 9:179-91, 2009
Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis
2009
Singh M, Madan T, Waters P, Sonar S, Singh SK, Kamran MF, Bernal AL, Sarma PU, Singh VK, Crouch EC, Kishore U
Mol Immunol 46:2363-2369, 2009
Identification and characterization of a laminin-binding protein of Aspergillus fumigatus: extracellular thaumatin domain protein (AfCalAp)
2009
Upadhyay SK, Mahajan L, Ramjee S, Singh Y, Basir SF, Madan T%
J Med Microbiol 58:714-22, 2009
Lung surfactant proteins A and D as pattern recognition proteins
2009
Waters P, Vaid M, Kishore U, Madan T
Adv Exp Med Biol 653: 74-97, 2009
Projects Ongoing
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Studies to understand the tertiary structure-dependence on antimicrobial activity of 2 novel peptides (Co-I, Funded by Department of Science and Technology)
- Proteomics of medically important fungus Aspergillus fumigatus to identify potential allergens/ antigens, virulent factors and proteins and pathways involved in drug resistance (Funded by Department of Science and Technology)
- Task Force on Infectious disease Handling, Storage and Research Facilities [COR0011] (Funded by Council of Scientific and Industrial Research)
- Task Force on Identification of potential drug targets [SMM003] (Funded by Council of Scientific and Industrial Research (CSIR)
- Task Force on “Asthmatic & Allergic Disorders Mitigation mission” TFBG (Funded by Council of Scientific and Industrial Research)
- Molecular Mechanisms of host-pathogen interactions : Role of lung surfactant proteins in genetic predisposition to respiratory infectious diseases GAP0008 (Funded by Indian National Science Academy Young Scientist Project)