Dr. Priyanka Parte
Scientist-E
Email: partep[at]nirrh[dot]res[dot]in/priyankaparte[at]rediffmail[dot]com
Phone: +(91-22) 2419-2005
Department: Gamete Immunobiology
Academic Background
- M.Sc. University of Mumbai (Applied Biology; 1992)
- M.Sc University of Edinburgh , Scotland , U.K. (Reproductive Biology; 1996)
- Ph.D. University of Mumbai , (Biochemistry; 2000)
- Post Doc University of Massachusetts, Worcester (Biochem & Mol. Pharmacol.; 2003-2004)
Professional Experience
| Scientist B (Research Officer) | 2002 – 2007 | National Institute for Research in Reproductive Health |
| NIH Post-doctoral fellow | 2003-04 | UMASS Med School, MA, USA (Biochemistry & Molecular Pharmacology) |
| Scientist C (Senior Research Officer) | 2007-2012 | National Institute for Research in Reproductive Health |
| Scientist D (Assistant Director) | 2012 – 2016 | National Institute for Research in Reproductive Health |
| Scientist E (Deputy Director) | 2016 onwards | National Institute for Research in Reproductive Health |
Research Interests
- Cell Motility
- Reproductive Biology
- Proteomics
Present
- Sweta Parab
- Vivian Lobo
- Pratibha Varma
- Veena Dalvi
- Shweta Bhagwat*
- Aniket Patankar
Awards & Achievements
- Two years training fellowship at the Centre for Reproductive Biology of the University of Edinburgh, Scotland, U.K., under the financial support of the Rockefeller Foundation from Oct 1994 – Sept 1996.
- ‘Best Young ESI Presenter’ award for Oral Presentation for the paper entitled “Temporal effect of tamoxifen on testicular cytochrome P450 gene expression and steroid concentration in adult male rats.” Presented at the 31st National Conference of Endocrine Society of India, 9–11 December, 2001.
- NIH Postdoctoral fellowship under the supervision of Professor David Kupfer, Dept of Biochemistry and Molecular Pharmcology at the UMASS Medical School at Worcester, MA from May, 2003 to May 2004.
- Six week training fellowship for the special topics course in “Frontiers in Reproduction” at Marine Biological Laboratories, Woods Hole, MA, from 5th May 17th June, 2007.
- Best Poster award for the work entitled ‘Sperm Phosphoproteome Profiling by DIGE / LCMSE Reveals Altered Proteomic Signature in Asthenozoospermatozoa’ presented at the IPCON Conference on ‘Trends in Translational Proteomics’ held in New Delhi Proteomic Society of India from 3rd to 5th April, 2011.
- Royan 16th International Research Award in the field of Embryology for research done entitled Tubulin Reversible Acetylation – Driving the Moves and the Moves behind the Drive on September 2, 2015 in Razi Conference Center, Tehran, Iran. Royan Institute, Tehran, Iran – 2nd Sept 2015
Publications
Acetylation/deacetylation and microtubule associated proteins influence flagellar axonemal stability and sperm motility.
2020
Chawan V, Yevate S, Gajbhiye R, Kulkarni V, Parte P
Biosci Rep
Chemotactic behavior of spermatozoa captured using a microfluidic chip.
2018
Bhagwat S, Sontakke S, K D, Parte P, Jadhav S.
Biomicrofluidics. 2018 Mar 29;12(2):024112. doi: 10.1063/1.5023574. eCollection 2018 Mar.
Correction to: HDAC6 deacetylates alpha tubulin in sperm and modulates sperm motility in Holtzman rat.
2018
Parab S, Shetty O, Gaonkar R, Balasinor N, Khole V, Parte P.
Cell Tissue Res 371(2):375, 2018.
Automated analysis of rat sperm motility in microchannels.
2018
Shukla SK, Bhagwat S, Sontakke S, Parte P, Jadhav S.
Biomed Physics Engineering Express 4: doi.org/10.1088/2057-1976/aab10d, 2018
Tubulin acetylation: A novel functional avenue for CDYL in sperm.
2017
Parab S, Dalvi V, Mylavaram S, Kishore A, Idicula-Thomas S, Sonawane S, Parte P.
Cytoskeleton 74: 331-342, 2017.
Developmental testicular expression, cloning, and characterization of rat HDAC6 in silico.
2017
Verma P, Shetty O, Parab S, Menezes K, and Parte P.
BioMed Res Intl doi:10.1155/2017/5170680, 2017
Monocyte proteomics reveals involvement of phosphorylated HSP27 in the Pathogenesis of Osteoporosis
2015
Daswani B, Gupta MK, Gavali S, Desai M, Sathe GJ, Patil A, Parte P, Sirdeshmukh R, Khatkhatay MI
Dis Markers 2015: 196589 ,2015
Glucose Regulated Protein 78 phosphoforms in sperm undergo dynamic changes during epididymal maturation
2015
Lobo V, Rao P, Gajbhiye R, Kulkarni V, Parte P
PLoS One DOI: 10
HDAC6 deacetylates alpha tubulin in sperm and modulates sperm motility in Holtzman rat
2015
Parab S, Shetty O, Gaonkar R, Balasinor N, Khole V, Parte P
Cell Tissue Res 359: 665-678, 2015
Acetylated alpha tubulin is reduced in individuals with poor sperm motility
2014
Bhagwat S, Dalvi V, Chandrasekhar D, Matthew T, Acharya K, Gajbhiye R, Kulkarni V, Sonawane S, Ghosalkar M and Parte P
Fertil Steril 101:95-104, 2014
Proteomics in reproductive biology: Beacon for unraveling the molecular complexities
2013
Upadhyay RD, Balasinor NH, Kumar AV, Sachdeva G, Parte P, Khambata K
Biochim Biophys Acta Proteins and Proteomics 1834: 8–15, 2013
Sperm Phosphoproteome profiling by Ultra Performance Liquid Chromatography followed by data independent analysis (LC-MSE) reveals altered proteomic signatures in Asthenozoospermia
2012
Parte PP, Rao P, Redij S, Lobo V, D’Souza SJ, Gajbhiye R, Kulkarni V, Parte PP, Rao P, Redij S, Lobo V, D’Souza SJ, Gajbhiye R, Kulkarni V
J Proteomics 75: 5861-5871, 2012
Estradiol affects androgen binding protein expression and fertilizing ability of spermatozoa in adult male rats
2006
Aleem M, Padwal V, Chowdhari J, Balasinor N, Parte P, Gill-Sharma MK
Mol Cell Endocrinol 253:1-13, 2006
Mechanism delineating differential effect of an antiestrogen, tamoxifen on the serum LH and FSH in adult male rats
2006
Balasinor N, Parte P, Gill-Sharma MK and Juneja HS
J Endocrinol Invest 29: 485-496, 2006
Naturally occurring anti albumin antibodies are responsible for false positivity in diagnosis of autoimmune premature ovarian failure
2006
Pires ES, Parte PP, Meherji PK, Khan SA, and Khole VV
J Histochem Cytochem 54: 397-405, 2006
Hyperprolactinemia affects spermiogenesis in adult male rats
2005
Aleem M, Choudhari J, Padwal V, Balasinor N, Parte P and Gill-Sharma MK
J Endocrinol Invest 28: 39-48, 2005
Cyproterone acetate affects protamine gene expression in the testis of adult male rat
2005
Aleem M, Padwal V, Choudhari J, Balasinor N, Parte P and Gill-Sharma MK
Contraception 71: 379–391, 2005
Effects of tamoxifen citrate on gene expression during nuclear chromatin condensation in male rats
2005
Aleem M, Padwal V, Choudhari J, Balasinor N, Parte P and Gill-Sharma MK
Asian J Androl 7: 311–321, 2005
Oxidation of tamoxifen by human FMO1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochrome P450s and hemoglobin
2005
Parte PP and Kupfer D
Drug Metab Dispos 33: 1446 -1452, 2005
Effect of paternal tamoxifen on the expression of insulin-like growth factor-2 (IGF-2) and insulin like growth factor type 1 receptor in the post – implantation rat embryos
2004
Kedia N, Parte P, Gill-Sharma MK and Balasinor N
Mol Reprod Dev 69 : 22-30, 2004
Antifertility effects of fluphenazine in adult male rat
2003
Gill-Sharma MK, Aleem M, Sethi G, Choudhary J, Padval V, D’Souza S, Balasinor N, Parte P and Juneja HS
J Endrocrinol Invest 26 : 316-26, 2003
Effects of oral tamoxifen treatment on semen characteristics and hormonal profile of male bonnet monkey
2003
Gill-Sharma MK, D’Souza S, Parte P, Balasinor N, Choudhary J, Majramkar DD, Aleem M, and Juneja HS
Contraception 67 : 409-413, 2003
Effect of paternal administration of an antiestrogen, tamoxifen on embryo development in rats
2002
Balasinor N, Sharma MK, Parte P, D’Souza S, Kedia N and Juneja HS
Mol Cell Endocrinol 190 : 159-166, 2002
Temporal effect of tamoxifen on cytochrome P450 side chain cleavage gene expression and steroid concentration in adult male rats
2002
Parte P, Balasinor N, Gill-Sharma MK, Mitra A and Juneja HS
J Steroid Biochem Mol Biol 82: 349-352, 2002
Effect of tamoxifen on sperm fertilising ability and preimplantation embryo development
2001
Balasinor N, Parte P, Gill-Sharma MK and Juneja HS
Mol Cell Endocrinol 178 : 199-206, 2001
Effect of intermittent treatment with tamoxifen on reproduction in male rats
2001
Gill-Sharma MK, Balasinor N and Parte P
Asian J Androl 3: 115-119, 2001
Effects of tamoxifen metabolites on fertility of male rat
2001
Gill-Sharma MK, Balasinor N, Parte P, Aleem M and Juneja HS
Contraception 63 : 103-109, 2001
Antifertility effects of estradiol in adult male rats
2001
Gill-Sharma MK, D’Souza S, Padwal V, Balasinor N, Aleem M, Parte P and Juneja HS
J Endocrinol Invest 24 : 598-607, 2001
Effect of Dihydrotestosterone implants on the fertility of male rats treated with tamoxifen
2000
Parte PP, Balasinor N, Gill-Sharma MK and Juneja HS
J Androl 21 : 525-533, 2000
Abnormalities in functional development of the sertoli cells in rats treated neonatally with diethylstilbestrol : possible role for estrogens in sertoli cell development
1998
Sharpe RM, Atanassova N, McKinnell C, Parte P, Turner KJ, Fisher JS, Kerr JB, Groome NP, McPherson S, Millar MR and Saunders PTK
Biol Reprod 59 : 1084-1094, 1998
Effects of tamoxifen on the fertility of male rats
1993
Gill-Sharma Manjit K, Gopalkrishnan K, Balasinor N, Parte P, Jayaraman S and Juneja HS
J Reprod Fertil 99 : 395-402, 1993
Assessment of bioactivity of WHO/NIH Research standard for inhibin (code 86/690) using two separate pituitary cell-culture systems
1993
Parte PP and Juneja HS
Horm Metab Res 25 : 356-359, 1993
Projects Ongoing
- Microtubule (MT) dynamics and sperm function: Involvement of tubulin acetylation/deacetylation – ICMR Medical Innovation Fund
- Defining the role of Glucose Regulated Protein 78 (GRP78) in Sperm Motility (Dept of Biotechnology/NIRRH)
- A study deciphering the role of HDAC6 in spermatogenesis. (DST-SERB)
- Microtubule (MT) dynamics and sperm function: involvement of tubulin acetylation/deacetylation.
- Development of a microfluidic device for good quality sperm selection for Assisted Reproductive Technologies (ART) (DBT)
Projects Completed
- Investigation of functional sperm proteins relevant to motility using the proteomics and in silico approach (Dept of Biotechnology).
- Role of HDAC6 and Cdyl gene in sperm motility (Dept of Science and Technology / ICMR)
- Characterization of the tubulin interactome involved in the orchestration of sperm flagellar motility (Dept of Biotechnology/ICMR)