Dr. Deepak Modi
Scientist-E
Email: deepaknmodi[at]yahoo[dot]com
Phone: +(91-22) 2419-2034
Department: Molecular and Cellular Biology
Academic Background
- Ph.D. University of Mumbai (Applied Biology; 2003)
- M.Sc. University of Bombay (Zoology; 1995)
Professional Experience
| Lecturer in Zoology | Wilson College , Mumbai University | 1995-1996 |
| Research Assistant | Wadia Hospital for Children, Mumbai | 1997-2001 |
| Scientist | NIRRH | 2002-till date |
Research Interests
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Cell and molecular biology
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Functional genomics
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Proteomics
Present
- Anuradha Mishra PhD student, UGC JRF
- Neha Singh PhD student
- Nancy Ashary (NIRRH fellow)
- Richa Sharma (DST Inspire)
- Stacy Colaco (ICMR Post Doctoral fellow)
- Noble Kurien (KSCSTE Post Doctoral Fellow)
- Anshul Bhide (Project JRF)
Past
- Dr Mosami Galvankar
- Mr Pradeep Bharitya (remove him from present)
- Rutwik Thengodkar
- Dr Shantashri Vaidya
- Dr Shipra Sharma
- Mr Varun Suresh
Awards & Achievements
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Recipient of NASI, National Academy of Science India, platinum jubilee young scientist award, 2007
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Recipient of the Innovative Young Biotechnologist Award (IYBA) for the year 2007.
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Recipient of the Indian National Academy of Science (INSA) Young Scientist Medal 2006
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Selected as one of the 16 international participants for the course work “Frontiers in Reproduction – 2003” Marine Biology Laboratory, Woods Hole, MA, USA
- Receipient of ICMR Tilak Venkoba Rao Award – 2010
Publications
Genetics of the human Y chromosome and its association with male infertility
2018
S Colaco, Modi D
Reproductive Biology and Endocrinology 16 (1), 14, 2018
Simplified approach for in-vitro production and purification of cell derived Cancer Antigen 15-3
2018
Shoaib Haidar, Paresh B Bhanushali, Kunal K Shukla, Modi D, Puri CP, Shamkant B Badgujar, Manoj Chugh
International journal of biological macromolecules 1456-1462, 2018
Embryo Implantation: War in times of love
2018
N Ashary, A Tiwari, Modi D
Endocrinology, 2018
Laheri S, Ashary N, Bhatt P and Modi D N
Journal of Assisted Reproduction and Genetics
Histochemical Staining of Collagen and Identification of Its Subtypes by Picrosirius Red Dye in Mouse Reproductive Tissues
2017
A. Bhutda, S, Surve, M. V., Anil, A., Kamath, K. G., Singh, N., Modi D, and Banerjee
Bio-protocol 7:21, e2592., 2017
Identification of motility-associated progesterone-responsive differentially phosphorylated proteins
2017
V Sagare-Patil, Modi D
Reproduction, Fertility and Development 29 (6), 1115-1129, 2017
Estrogen is essential but not sufficient to induce endometriosis
2017
Mosami Galvankar, Neha Singh, Modi D
Journal of biosciences 42: 2, 251-263, 2017
Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion
2017
Geeta Godbole, Pankaj Suman, Ankita Malik, Mosami Galvankar, Niraj Joshi, Asgerally Fazleabas, Satish Kumar Gupta, Modi D
Endocrinology 158 (8) 2618-2633, 2017
Progesterone requires heat shock protein 90 (HSP90) in human sperm to regulate motility and acrosome reaction
2017
Vrushali Sagare-Patil, Rashmi Bhilawadikar, Mosami Galvankar, Kusum Zaveri, Indira Hinduja, Modi D
Journal of assisted reproduction and genetics 34: 4 495-503, 2017
Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary
2017
Saniya Laheri, Modi D, Purvi Bhatt
Journal of biosciences 42 (1) 69-80, 2017
Assessment of oxidative stress in serum of pulmonary tuberculosis patients
2017
Vishal Wagh, Shreewardhan Rajopadhye, Sandeepan Mukherjee, Anant Urhekar, Modi D
International Journal of Research in Medical Sciences 4 (8) 3328-3332, 2017
Role of Y Chromosome Microdeletions in Clinical Evaluation of Infertile Males
2017
Modi D, Colaco S, Aiman Lakdawala
MGM Journal of Medical Sciences 4 (2) 79-88, 2017
Levels of microRNA miR-16 and miR-155 are altered in serum of patients with tuberculosis and associate with responses to therapy
2017
Vishal Wagh, Anant Urhekar, Modi D
Tuberculosis 102: 24-30, 2017
Decidual control of trophoblast invasion.
2016
Sharma S, Godbole G, Modi D.
Am J Reprod Immunol 75: 341-50, 2016.
Deletion of GOLGA2P3Y but not GOLGA2P2Y is a risk factor for oligozoospermia.
2016
Sen S, Agarwal R, Ambulkar P, Hinduja I, Zaveri K, Gokral J, Pal A, Modi D
Reproductive Biomed Online 32: 218-24, 2016.
Membrane vesicles of group B streptococcus disrupt feto-maternal barrier leading to preterm birth.
2016
Surve MV, Anil A, Kamath KG, Bhutda S, Sthanam LK, Pradhan A, Srivastava R, Basu B, Dutta S, Sen S, Modi D, Banerje A.
PLoS Pathog Sep 1;12(9):e1005816.
Physiology of Embryo Endometrial cross talk
2015
Modi D and Bhartiya P
Biomed Res J 2: 83-104, 2015
Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions
2015
Sen S, Ambulkar P, Hinduja I, Zaveri K, Gokral J, Pal A, Modi D
J Assist Reprod Genet 32: 1333-41, 2015 (IF: 1
56 Cellular ontogeny of RBMY during human spermatogenesis and its role in sperm motility
2013
Abid S, Sagare-Patil V, Gokral J, Modi D
J Biosci 38:85-92, 2013
HIV gp120 induced gene expression signatures in vaginal epithelial cells
2013
Fanibunda SE, Modi DN and Bandivdekar AH
Microb Infec 15: 806-815, 2013
Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction
2013
Sagare-Patil V, Vernekar M, Galvankar M, Modi D
Mol Cell Endocrinol 374: 82-91, 2013
Y chromosome microdeletions in infertile men: prevalence, phenotypes and screening markers for the Indian population
2013
Sen S, Pasi AR, Dada R, Shamsi MB, Modi D
J Assist Reprod Genet 30: 413–422, 2013
Endometrial biology during trophoblast invasion
2012
Modi DN,Godbole G, Suman P, Gupta SK
Frontiers in Bioscience S4, 1151-1171, 2012
Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa
2012
Sagare-Patil V, Galvankar M, Satiya M, Bhandari B, Gupta S K and Modi D
Intl J Androl 35: 633–644, 2012
AP-1 transcription factors, mucin-type molecules and MMPs regulate the IL-11 mediated invasiveness of JEG-3 and HTR-8/SVneo trophoblastic cells
2012
Suman P, Godbole G, Thakur R, Morales-Prieto DM, Modi DN, Markert UR, Gupta SK
PLoS One
HIV gp 120 Binds to Mannose Receptor on Vaginal Epithelial cells and Induces Production of Matrix Metalloproteinases
2011
Fanibunda SE, Modi DN, Gokral JS and Bandivdekar AH
PloS ONE 6: 11 e28014, 2011
Decidualized endometrial stromal cell derived factors promote trophoblast invasion
2011
Godbole G, Suman P, Gupta SK, Modi D
Fertil Steril 95:1278-1283, 2011
Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorhea
2010
Achrekar SK, Modi DN, Meherji PK, Patel ZM and Mahale SD
J Assis Reprod Genet 27: 317-326, 2010
High affinity of seminal plasma PSP94 to human immunoglobulin is through the Fab domain
2010
Jagtap DD, Modi DN, Kumar M, Pathak BR, Mahale SD
Biochem Biophy Acta: Prot Proteom 1804: 1889-1894, 2010
Follicle-stimulating hormone receptor polymorphism (Thr307 Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women
2009
Achrekar SK, Modi DN, Desai SK, Mangoli VS, Mangoli RV, Mahale SD
Fertil Steril 91: 432-439, 2009
Poor ovarian response to gonadotropin stimulation is associated with FSH receptor polymorphism
2009
Achrekar SK, Modi DN, Desai SK, Mangoli VS, Mangoli RV, Mahale SD
Reprod Biomed Onl 18: 509-515, 2009
Stage – specific localization and expression of c-kit in the adult human testis
2009
Bhartiya D, Unni S, Modi D, Pathak S, Dhabalia J
J Histochem and Cytochem 57(9): 861-869, 2009
Longer CAG repeat length in the androgen receptor gene is associated with premature ovarian failure
2009
Chatterjee S, Singh R, Kadam S, Maitra A, Thangaraj K, Meherji P, Modi D
Hum Reprod 24:3230-5, 2009
Gene expression profiling during early folliculogenesis in the mouse ovary
2009
Dharma SJ, Modi DN, Nandedkar TD
Fertil Steril 91: 2025-2036, 2009
Expression of Endometrial Protein Kinase A during Early Pregnancy in Bonnet Monkeys (Macaca radiata)
2009
Rosario GX, Katkam RR, Joshi SN, Modi DN, Hinduja I, Zaveri K, Puri CP and Sachdeva G
Biol Reprod 81: 1172-1181, 2009
Stage-specific localization and expression of c-kit in the adult human testis
2009
Unni S, Modi D, Pathak S, Dhabalia J and Bhartiya D
J Histochem Cytochem 57: 861–869, 2009
Altered expression of progesterone receptors in testis of infertile man
2008
Abid S, Maitra A, Gokral JS, Meherji PK, Pires E, Kadam S and Modi DN
RBM Online 17: 175-184, 2008(IF: 3
Identification of genes regulated by an interaction between ?v?3 integrin and vitronectin in murine deciduas
2008
Mangale SS, Modi DN and Reddy KVR
Reprod Fertil Dev 20: 311-319, 2008
Screening for FOXL2 gene mutations in women with premature ovarian failure: an Indian experience
2007
Chatterjee S, Modi DN, Maitra A, Kadam S, Patel ZM, Gokral JS and Meherji PK
RBM Online 15: 555-560, 2007
Regulation of homeobox A10 expression in the primate endom etrium by progesterone and embryonic stimuli
2007
Godbole GB, Modi DN and Puri CP
Reproduction 134: 513-523, 2007
Exposure of adult rats to estradiol valerate induces ovarian cyst with early senescence of follicles
2007
Shirwalkar H, Modi DN and Maitra A
Mol Cell Endocrinol 272: 22-37, 2007(IF: 2
Developmental expression and cellular distribution of Mullerian inhibiting substance in the primate ovary
2006
Modi D, Bhartiya D and Puri CP
Reprod 132: 443-453, 2006
Differential gene expression in transition of primordial to preantral follicles in mouse ovary
2006
Nandedkar TD, Dharma S, Modi D, D’Souza S
Gamet Biol Suppl 63: 57-68, 2006
Ontogeny and cellular localization of SRY transcripts in the human testes and its detection in spermatozoa
2005
Modi D, Shah C, Sachdeva G, Gadkar S, Bhartiya D and Puri C
Reproduction 130: 603-613, 2005
Rab Coupling Protein (RCP): a novel target of progesterone action in primate endometrium
2005
Patil VS, Sachdeva G, Modi DN, Katkam RR, Manjramkar DD, Hinduja I and Puri CP
J Mol Endocrinol 35: 357-372, 2005
Morphological events in the primate endometrium in presence of a preimplantation embryo detected by the serum preimplantation factor bioassay
2005
Rosario G, Modi D, Sachdeva G, Manjramkar DD and Puri CP
Hum Reprod 20: 61-71, 2005
Endometrial expression of immunomodulatory cytokines and their regulators during early pregnancy in bonnet monkeys (Macaca radiata)
2005
Rosario G, Sachdeva G, Manjramkar DD, Modi DN, Meherji PK and Puri CP
Hum Reprod 20: 3039-3046, 2005
Coexistence of intracellular and membrane-bound progress receptors in human testis
2005
Shah C, Modi D, Sachdeva G, Gadkar S and Puri CP
J Clin Endocrinol Metab 90: 474-483, 2005
Progesterone receptors in the testis: cellular and molecular characterization
2005
Shah C, Modi D, Sachdeva G, Gadkar-Sable S, D’Souza S and Puri CP
Reprod Nut Dev 45: 210-211, 2005
N-terminal region of progesterone receptor B isoform in human spermatozoa
2005
Shah C, Modi D, Sachdeva G, Gadkar S, D`Souza S and Puri, CP
Intl J Androl 28:360-371, 2005
Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads
2003
Modi DN, Sane S, and Bhartiya D
Mol Hum Reprod 9: 219-225, 2003
Down syndrome: a study of chromosomal mosaicism
2003
Modi DN, Barde P and Bhartiya D
Reprod Biomed Online 6 : 499-503, 2003
In vitro effects of aspirin and salicylate on erythrocytes:size and+/K+ Atpase activity
2003
Modi DN and Merchant MA
Indian J Pharmacol 35 : 27-31, 2003
Progesterone receptors on human spermatozoa
2003
Shah C, Modi D, Gadkar S, Sachdeva G and Puri CP
Indian J Exp Biol 41: 773-780, 2003
Projects Ongoing
- Deciphering the role of homeobox protein HOXA10 in endometrial receptivity and decidualization ( Funded by Department of Biotechnology)
- Identification and characterization of a novel transmembrane receptor for progesterone (Funded by ICMR Medical Innovation Grant)
- Sperm Phospho-Proteomics: Elucidating the Signal Transduction Mechanisms of Progesterone Action ( Funded by Department of Biotechnology)
- Identification and characterization of progesterone receptors in human testis and spermatozoa ( Funded by ICMR-NIRRH core grant)