Dr. Deepa Bhartiya
Scientist-F
Email: deepa.bhartiya[at]yahoo[dot]in, bhartiyad[at]nirrh[dot]res[dot]in
Phone: +(91-22) 2419-2012
Department: Stem Cell Biology
Academic Background
- M.Sc. Punjab University , Patiala , (Zoology)
- Ph.D. Central Drug Research Institute, Lucknow (Zoology)
Professional Experience
| Post Doc Fellow | Dept of Pathology, Uniformed Services University of Health Sciences, Bethesda , Maryland , USA | 1989-1991 |
| Fogarty Fellow | Development Endocrinology Branch, National Inst. of Child and Development, National Inst of Health (NIH), Bethesda , Maryland , USA | 1991-1994 |
| Scientist | Cell Biology Dept, BJ Wadia Hospital for Children, Mumbai | 1995- 2000 |
| Scientist | Genetics, Reliance Life Sciences Pvt. Ltd, Mumbai | 2001- 2002 |
| Scientist | NIRRH |
2003- Till Date
|
| Visiting Scientist | Three months Visiting Associateship (sponsored by DBT) for Training at Buck Institute, California, USA. | 2008 |
| Visiting Scientist | Trained during a three day NIH sponsored ES Cell Course at Stem Cell Centre, University of Minnesota , MO , USA | 2008 |
| Visiting Scientist |
|
Research Interests
- Pluripotent stem cells and Regenerative medicine
- Fertility issues of cancer patients
Present
Ms Sandhya Anand
Mr Hiren Patel
Ms Ambreen Shaikh
Ms Ankita Kaushik
Ms Diksha Sharma
Past
Ms Prajakta Berde (M.Sc.)
Ms Lata Shamale (M.Sc.)
Ms Chhaya Kapadia (Ph.D.)
Ms Shamim Sheikh (Ph.D.)
Ms Rajbinder Kaur (Ph.D.)
Mr Deepak Modi (Ph.D.)
Mr Neeraj Kumar (Ph.D.)
Ms. Sreepoorna Unni (Ph.D.)
Ms Seema Parte (Ph.D.)
Mr Prasad Pethe (Ph.D)
Woman Scientist (DST)
Dr Kalpana Sriraman (completed)
Dr Ranita Ganguly (Ongoing)
Awards & Achievements
- Awarded ICMR International Fellowship for Senior Indian Biomedical Scientist for the year 2013-14 in the lab of Prof Al-Handy Ayman, Scientific Director, Department of Obstetrics and Gynecology, Meharry Medical College, Tennessee, USA
- The Ranbaxy Science Scholar Award 2012 for Young Scientist in the Biomedical Sciences Stream awarded to Ms Seema Parte (PhD student), Ranbaxy Research and Development Centre, Gurgaon, Haryana on 2nd November 2012
- Shared the prestigious Labhsetwar National Award for the year 2011 for the scientific contribution in the area of pluripotent stem cells in mammalian gonads. The award has been constituted by Drs. Lata and Anant Labhsetwar Foundation, USA and Labhsetwar Charitable trust, Nagpur. The award was conferred during the International Conference on Reproductive Health and 22nd Annual Meeting of the Indian Society for the Study of Reproduction and Fertility (ISSRF) held at New Delhi from 19th -21st February, 2012.
- Her students Mr Hiren Patel (NIH Travel Award – American Society of Andrology meeting, USA, 2015), Ms Ambreen Shaikh and Ms Sandhya Anand (Stem Cell Network travel award – Till & McCulloch meeting, Canada, 2015 and 2016) have received international travel awards for attending international conferences.
Publications
Pluripotent Stem cells in adult tissues: Struggling to be acknowledged over two decades.
2018
Bhartiya D.
Stem Cell Rev. 2017 Dec;13(6):713-724. doi: 10.1007/s12015-017-9756-y. Review.
Improved understanding of very small embryonic-like stem cells in adult mammalian ovary.
2018
Bhartiya D, Patel H, Parte S.
Hum Reprod. 2018 Feb 21. doi: 10.1093/humrep/dey039. [Epub ahead of print]
Letter to the Editor:Being Pluripotent, Bone Marrow VSELs rather than HSCs have the potential to regenerate other adult organs.
2018
Bhartiya D.
Stem Cells 2018 Jan 18. doi: 10.1002/stem.2782 [Epub ahead of print] Review.
The need to revisit the definition of mesenchymal and adult stem cells based on their functional attributes.
2018
Bhartiya D.
Stem Cell Res Ther. 2018 Mar 27;9(1):78. doi: 10.1186/s13287-018-0833-1.
Dynamics of Bone Marrow VSELs and HSCs in Response to Treatment with Gonadotropin and Steroid Hormones, during Pregnancy and Evidence to Support Their Asymmetric/Symmetric Cell Divisions.
2018
Ganguly R, Metkari S, Bhartiya D.
Stem Cell Rev. 2018 Feb;14(1):110-124. doi: 10.1007/s12015-017-9781-x.
Ovarian stem cells- resolving controversies.
2018
Bhartiya D and Patel H.
J Assis Reprod Genet 35: 393-398, 2018
Improved understanding of very small embryonic-like stem cells in adult mammalian ovary
2018
Bhartiya D, Patel H, Parte S
Hum Reprod. 2018;33(5):978-979.
Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage.
2018
Pursani V, Bhartiya D, Tanavde V, Bashir M, Sampath P
Stem Cell Res Ther. 2018;9(1):97.
Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium
2018
James K, Bhartiya D, Ganguly R, Kaushik A, Gala K, Singh P, Metkari SM.
J Ovarian Res. 2018;11(1):83.
Novel insights into adult and cancer stem cell biology
2018
Bhartiya D, Patel H, Ganguly R, Shaikh A, Shukla Y, Sharma D, Singh P.
Stem Cells Dev. 2018.doi: 10.1089/scd.2018.0118.
Pluripotent very small embryonic-like stem cells in adult testes – an alternate premise to explain testicular germ cell tumors.
2018
Kaushik A, Bhartiya D.
Stem Cell Rev. 2018. doi: 10.1007/s12015-018-9848-3.
Further Characterization of Adult Sheep Ovarian Stem Cells and Their Involvement in Neo-oogenesis and Follicle Assembly
2018
Patel H, Bhartiya D, Parte S
Journal of Ovarian Research. 2018; 11(1):3
Letter to the Editor: Rejuvenate eggs or regenerate ovary?
2017
Bhartiya D.
Mol Cell Endocrinol. 2017 May 5; 446:111-113
Mouse bone marrow VSELs exhibit differentiation into three embryonic germ lineages and germ & hematopoietic cells in culture.
2017
Shaikh A, Anand S, Kapoor S, Ganguly R, Bhartiya D.
Stem Cell Rev. 2017;13(2):202-216.
Shifting gears from embryonic to very small embryonic-like stem cells for regenerative medicine.
2017
Bhartiya D.
Ind J Med Res 146: 15-21, 2017
Effects of oncotherapy on testicular stem cells and niche.
2017
Bhartiya D, Anand S
Mol Hum Reprod 23: 654–655, 2017
Evaluating KIND1 human embryonic stem cell-derived pancreatic progenitors to ameliorate streptozotocin induced diabetes in mice.
2017
Pursani V, Kapoor S, Metkari SM, Nair P and Bhartiya D.
Ind J Med Res 146: 244-254, 2017
Making gametes from alternate sources of stem cells: past, present and future.
2017
Bhartiya D, Anand S, Patel H, Parte S
Reproductive Biology & Endocrinology. 2017; 15(1):89
Underlying mechanisms that restore spermatogenesis on transplanting healthy niche cells in busulphan treated mouse testis
2016
Anand S, Bhartiya D, Sriraman K, Mallick A
Stem Cell Rev Sep 23, 2016
Ubiquitous expression of FSH/LH/hCG receptors, OCT-4, and CD133 in adult organs and cancers reflects novel VSELs biology
2016
Bhartiya D
J Reproductive Health and Medicine, 2: 33-36, 2016
Novel Action of FSH on Stem Cells in Adult Mammalian Ovary Induces Postnatal Oogenesis and Primordial Follicle Assembly
2016
Bhartiya D, Parte S, Patel H, Sriraman K, Zaveri K, Hinduja I
Stem Cells Int 2016:5096596, 2016
An update on endometrial stem cells and progenitors
2016
Bhartiya D
Hum Reprod Update, 2016
Endogenous, very small embryonic-like stem cells: critical review, therapeutic potential and a look ahead
2016
Bhartiya D, Shaikh A, Anand S, Patel H, Kapoor S, Sriraman K, Parte S, Unni S
Hum Reprod Update, 2016
Is the improved function of STZ treated pancreas truly due to transdifferentiation/fusion of transplanted MSCs?
2016
Bhartiya D
Indian J Med Res 143(1):111-2, 2016
Stem cells to replace or regenerate the diabetic pancreas: Huge potential & existing hurdles
2016
Bhartiya D
Indian J Med Res 143: 267-274, 2016
National multicentric M13 Stem Cell Trial reports negative outcome – Need to look at VSELs as an alternative to bone marrow MNCs for cardiac regeneration
2016
Bhartiya D
Indian J Med Res 143: 830-832, 2016
Very small embryonic-like stem cells (VSELs) can avoid legal, ethical and safety issues associated with Oncofertility
2016
Bhartiya D
JAMA Oncol 2(5):689, 2016
Testicular stem cells express follicle-stimulating hormone receptors and are directly modulated by FSH
2016
Patel H and Bhartiya D
Reproductive Sciences, 2016
Testicular stem cells express follicle-stimulating hormone receptors and are directly modulated by FSH
2016
Patel H and Bhartiya D
Reproductive Sciences, 2016
Delineating the effects of 5 fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells
2016
Shaikh A, Bhartiya D, Kapoor S, Nimkar H
Stem Cell Res Ther 7(1):59, 2016
Bioconductive 3D nano-composite constructs with tunable elasticity to initiate stem cell growth and induce bone mineralization
2016
Sagar N, Khanna K, Sardesai VS, Singh AK, Temgire M, Kalita MP, Kadam SS, Soni VP, Bhartiya D, Bellare JR
Mater Sci Eng C Mater Biol Appl 69: 700-14, 2016
Do somatic cells de-differentiate/trans-differentiate or VSELs initiate cancer and explain plasticity in adult tissues?
2016
Bhartiya D and Ganguly R.
J Cancer Stem Cell Research
National multicentric M13 Stem Cell Trial reports negative outcome – Need to look at VSELs as an alternative to bone marrow MNCs for cardiac regeneration.
2016
Bhartiya D.
Indian J Med Res 143: 830-832, 2016
Chemoablated mouse seminiferous tubular cells enriched for very small embryonic-like stem cells undergo spontaneous spermatogenesis in vitro
2015
Anand S, Patel H, Bhartiya D
Reprod Biol Endocrinol 13: 33, 2015
Novel Action of FSH on Stem Cells in Adult Mammalian Ovary Induces Postnatal Oogenesis and Primordial Follicle Assembly
2015
Bhartiya D, Parte S, Patel H, Sriraman K, Zaveri K, Hinduja I
Stem Cells Int 2015
Ovarian Stem cells are always accompanied by very small embryonic-like stem cells in adult mammalian ovary
2015
Bhartiya D
J Ovarian Res 8:70, 2015 (IF: 2
Intricacies of pluripotency
2015
Bhartiya D
J Stem Cells Regen Med 30; 11: 2-6, 2015
VSELs may obviate cryobanking of gonadal tissue in cancer patients for fertility preservation
2015
Bhartiya D, Anand S, Parte S
J Ovarian Res 8:75, 2015
Very small embryonic-like stem cells are involved in pancreatic regeneration and their dysfunction with age may lead to diabetes and cancer
2015
Bhartiya D, Patel H
Stem Cell Res Ther 6:96, 2015
FSH-FSHR3-Stem cells in ovary surface epithelium: Basis for adult ovarian biology, failure, aging and cancer
2015
Bhartiya D and Singh J
Reproduction 149:R35-R48, 2015
Stem cells, progenitors & regenerative medicine: A retrospection
2015
Bhartiya D
Indian J Med Res 141: 154;161, 2015
Very small embryonic-like stem cells are the elusive mouse endometrial stem cells–a pilot study
2015
Gunjal P, Bhartiya D, Metkari S, Manjramkar D, Patel H
J Ovarian Res 8(1):9, 2015
Isolation and characterization of stem cells in the adult mammalian ovary
2015
Parte S, Patel H, Sriraman K, Bhartiya D
Methods Mol Biol 1235:203-229, 2015
Lineage specific expression of Polycomb Group Proteins in human embryonic stem cells in vitro
2015
Pethe P, Pursani V, Bhartiya D
Cell Biol Int 39:600-610, 2015
Molecular and phenotypic characterization of CD133 and SSEA4 enriched very small embryonic-like stem cells in human cord blood
2015
Shaikh A, Nagvenkar P, Pethe P, Hinduja I, Bhartiya D
Leukemia 29:1909-17, 2015
Mouse Ovarian Very Small Embryonic-Like Stem Cells Resist Chemotherapy and Retain Ability to Initiate Oocyte-Specific Differentiation
2015
Sriraman K, Bhartiya D, Anand S, Bhutda S
Reprod Sci 22: 884-903, 2015
Very small embryonic-like stem cells survive and restore spermatogenesis after busulphan treatment in mouse testis
2014
Anand S, Bhartiya D, Sriraman K, Patel H and Manjramkar DD
J Stem Cell Res Ther 4:216, 2014
Very small embryonic-like stem cells are involved in regeneration of mouse pancreas post-pancreatectomy
2014
Bhartiya D, Mundekar A, Mahale V and Patel H
Stem Cell Res Ther 5:106, 2014
Making gametes from pluripotent stem cells – a promising role for very small embryonic-like stem cells
2014
Bhartiya D, Hinduja I, Patel H and Bhilawadikar R
Reprod Biol Endocrinol 12:114, 2014
Dynamics associated with spontaneous differentiation of ovarian stem cells in vitro
2014
Parte S, Bhartiya D, Patel H, Daithankar V, Chauhan A, Zaveri K and Hinduja I
J Ovarian Res 7:25, 2014
An ideal oocyte activation protocol and embryo culture conditions for somatic cell nuclear transfer using sheep oocytes
2014
Patel H, Chougule S, Chohan P, Shah N and Bhartiya D
Indian J Exp Biol 52: 925-34, 2014
Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro
2014
Pethe P, Nagvenkar P and Bhartiya D
BMC Cell Biol 15:18, 2014
Very small embryonic-like stem cells: implications in reproductive biology
2013
Bhartiya D, Unni S, Parte S, Anand S
Biomed Res Intl Epub 2013 Feb 13
Neonatal exposure to estrogens affects very small embryonic-like stem cells (VSELs) leading to various pathologies including cancer
2013
Bhartiya D, Sriraman K, Bhutda S, Mulla S, Modak H
J Can Stem Cell Res, 2013
Are mesenchymal cells indeed pluripotent stem cells or just stromal cells? OCT-4 and VSELs Biology has led to better understanding
2013
Bhartiya D
Stem Cells Intl Epub 547501, Sep 25, 2013
Ovarian stem cells: absence of evidence is not evidence of absence
2013
Bhartiya D, Sriraman K, Parte S, Patel H
J Ovarian Res 6:65, 2013
Stimulation of ovarian stem cells by follicle stimulating hormone and basic fibroblast growth factor during cortical tissue culture
2013
Parte S, Bhartiya D, Manjramkar DD, Chauhan A, Joshi A
J Ovarian Res 6:20, 2013
Follicle stimulating hormone modulates ovarian stem cells through alternately spliced receptor variant FSH-R3
2013
Patel H, Bhartiya D, Parte S, Gunjal P, Vedulkar S, Bhatt M
J Ovarian Res 2013
Pluripotent stem cells for cardiac regeneration: Overview of recent advances & emerging trends
2013
Pawani H, Bhartiya D
Indian J Med Res 137: 270-282, 2013
Differentiation of human ES cell line KIND-2 to yield tripotent cardiovascular progenitors
2013
Pawani H, Nagvenkar P, Pethe P, Bhartiya D
In Vitro Cell Dev Biol Anim 49: 82-93, 2013
Stem cells in reproductive tissues: from the basics to clinics
2013
Virant-Klun I, Skutella T, Bhartiya D, Jin X
Biomed Res Intl 2013
Very small embryonic-like stem cells with maximum regenerative potential get discarded during cord blood banking and bone marrow processing for autologous stem cell therapy
2012
Bhartiya D, Shaikh A, Nagvenkar P, Sandhya K, Pethe P, Pawani H,Mohanty S, Rao SGA, Hinduja I and Zaveri K
Stem Cells Dev 21: 1-6, 2012
Cellular origin of testis derived pluripotent stem cells: A case for very small embryonic-like stem cells (VSELs)
2012
Bhartiya D, Kasiviswanathan S, Shaikh A
Stem Cells Dev 21: 670-674, 2012
Stem cell interaction with somatic niche may hold the key to fertility restoration in cancer patients
2012
Bhartiya D, Sriraman K and Parte S
Obstet Gynecol Int 2012
Gonadotropin treatment augments postnatal oogenesis and primordial follicle assembly in adult mouse ovaries?
2012
Bhartiya D, Sriraman K, Gunjal P, Modak H
J Ovarian Res 5:32, 2012
Pluripotent VSELs get discarded during cord blood & bone marrow processing
2012
Bhartiya D
Stem Cells Dev 21: 2563-64, 2012
The continued presence of stem cells and oogonia in the adult mammalian ovary
2012
Bhartiya D
Hum Reprod (Letter to Editor) 27: 938, 2012
Effect of age, sample state and concentration of cryoprotectant on efficient cryopreservation of testicular tissue
2012
Unni S, Kasiwisvanathan S, Dsouza S, Khavale S, Mukherjee S, Patwardhan S, and Bhartiya D
Fertility Sterility 97: 200-8e1, 2012
Evaluating differentiation propensity of in-house derived human embryonic stem cell lines KIND-1 and KIND-2
2011
Nagvenkar P, Pethe P, Pawani H, Telang J, Kumar N, Hinduja I, Zaveri K, Bhartiya D
In Vitro Cell Dev Biol Ani 47: 406-419, 2011
Detection, characterization and spontaneous differentiation in vitro of very small embryonic-like putative stem cells in adult mammalian ovary
2011
Parte S, Bhartiya D, Daithankar V, Salvi V, Zaveri K, Hinduja I
Stem Cells and Dev 20:1451-1464, 2011
Newer insights into premeiotic development of germ cells in adult human testis using oct-4 as a stem cell marker
2010
Bhartiya D, Kasiviswanathan S, Unni SK, Pethe P, Dhabalia JV, Patwardhan S, Tongaonkar HB
J Histochem Cytochem 58:1093-1106, 2010
Role of TGFbeta and myofibroblasts in supporting the propagation of human embryonic stem cells in vitro
2010
Kumar N, Pethe P, Bhartiya D
Intl J Dev Biol 54: 1329-1336, 2010
Stage – specific localization and expression of c-kit in the adult human testis
2009
Bhartiya D, Unni S, Modi D, Pathak S, Dhabalia J
J Histochem and Cytochem 57(9): 861-869, 2009
Derivation and characterization of two genetically unique human embryonic stem cell lines on in-house derived human feeders
2009
Bhartiya D, Kumar N, Hinduja I, Nagvenkar P, Pillai L, Agrawal P, Zaveri K, Mukadam L, Telang J, Desai S, Mangoli V, Mangoli R, Padgaonkar S, Kaur G, Puri C
Stem Cells Dev 18: 67-77, 2009
Derivation and characterization of two genetically unique human embryonic stem cell lines on in-house derived human feeders
2009
Kumar N, Hinduja I, Nagvenkar P, Pillai L, Agrawal P, Zaveri K, Mukadam L, Telang J, Desai S, Mangoli V, Mangoli R, Padgaonkar S, Kaur G, Puri C and Bhartiya D
Stem Cells Dev 18: 67-77, 2009
Sheep parthenogenesis and somatic cell nuclear transfer using Polscope
2009
Nandedkar P, Chohan P, Patwardhan A, Gaikwad S and Bhartiya D
Ind J Exptl Biol 47: 550-558, 2009
Stage-specific localization and expression of c-kit in the adult human testis
2009
Unni S, Modi D, Pathak S, Dhabalia J and Bhartiya D
J Histochem Cytochem 57: 861–869, 2009
Stem cells matter to the heart
2009
Bhartiya D, Pillai P
Nature India
Human somatic cell nuclear transfer and parthenogenesis: preliminary indian experience
2008
Bhartiya D, Ritchie W, Hinduja I, Nandedkar P, Zaveri K, Mukadam L, Chohan P, Patwardhan A, Nagvenkar P, Kumar N, Tat P, Richings N, Verma P
J Stem Cells 3: 255-264, 2008
Developmental expression and cellular distribution of Mullerian inhibiting substance in the primate ovary
2006
Modi D, Bhartiya D and Puri CP
Reprod 132: 443-453, 2006
Ontogeny and cellular localization of SRY transcripts in the human testes and its detection in spermatozoa
2005
Modi D, Shah C, Sachdeva G, Gadkar S, Bhartiya D and Puri C
Reproduction 130: 603-613, 2005
Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads
2003
Modi DN, Sane S, and Bhartiya D
Mol Hum Reprod 9: 219-225, 2003
Down syndrome: a study of chromosomal mosaicism
2003
Modi DN, Barde P and Bhartiya D
Reprod Biomed Online 6 : 499-503, 2003
Growth hormone receptor gene expression in the mouse uterus : Modulation by gonadal steroids
1994
Sharara FI, Bhartiya D and Nieman LK
J Soc Gynecol Invest 1: 285-289, 1994
Making gametes from pluripotent stem cells: embryonic stem cells or very small embryonic-like stem cells?
Bhartiya D, Anand S, Patel H.
Stem Cell Investig Oct 18; 3:57, 2016.
Projects Ongoing
- Preclinical studies using human ES cells derived cardio-vascular tripotent progenitors (Funded by ICMR, Department of Health Research)
- Preclinical studies using human ES cells derived islet progenitors (Funded by ICMR, Department of Health Research)
Projects Completed
- Isolation and propagation in vitro of VSELs from adult gonadal tissue and 3D maturation of germ cells. (Funded by Ministry of Science and Technology, Department of Biotechnology)
- Differentiation and characterization of cardiac progenitor cells and early cardiomyocytes derived from indigenously developed human embryonic stem cell lines. (Funded by Ministry of Science and Technology, Department of Biotechnology)
- Derivation of additional human embryonic stem cell lines from spare and discarded embryos and their characterization. (Funded by Ministry of Science and Technology, Department of Biotechnology)
- Lineage specific differentiation of human embryonic stem cells into insulin producing cells. (Funded by Ministry of Science and Technology, Department of Biotechnology)
- Development of non-human primate (Marmoset) ES cells as a regenerative source for cell therapy. (Funded by Ministry of Science and Technology, Department of Biotechnology)
- To establish technologies of parthenogenesis and somatic cell nuclear transfer (SCNT) using sheep eggs.(Funded by Ministry of Science and Technology, Department of Biotechnology)
- To establish human embryonic stem (hES) cell lines without mouse feeder (MEF) layers and study factors in MEF layer that prevent differentiation of hES cells in Vitro. (Funded by Ministry of Science and Technology, Department of Biotechnology )
- To standardize protocols for cryopreservation of gonadal tissue and study follicle growth in SCID mice. (Funded by DST, Ministry of Science and Technology, New Delhi)