Genetic Research Centre



About Us

 

 

 

 

 

 


The centre has pioneered the use of techniques like T-FISH, M-FISH and Sperm-FISH for diagnosis of genetic anomalies. We have standardized the technique of whole chromosome painting to identify unbalanced cryptic chromosomal rearrangements in patients with recurrent spontaneous abortions. Screening for 22q11 microdeletion has been undertaken to ascertain its association with congenital heart disease. We are studying the role of SRY in sex determination of individuals with paradoxical sexual development (XX males and XY females). The centre has initiated pre-implantation genetic screening of embryos for aneuploidies in collaboration with an IVF centre. We are also striving to establish single cell PCR for diagnosis of Fragile X syndrome and b thalassaemia. The centre is studying association of SNPs in MTHFR gene with neural tube defects and in CCR5 gene with HIV transmission, progression and prevention.

Laboratory facilities:

  • Karyotyping
  • Fluorescent in-situ hybridization (FISH)
  • T-FISH, M-FISH, SPERM FISH, Leucocyte FISH
  • Immunocytochemical test and MSPCR for Fragile X syndrome

Education and Training programmes provided by the center:

The centre imparts a genetic lecture series for undergraduate and graduate SNDT nursing students as part of their curriculum. We also develop educational manuals and pamphlets for doctors, paramedical staff and general public.